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Antagonistic circuits mediating infanticide and maternal care in female mice

Author

Listed:
  • Long Mei

    (New York University Langone Medical Center)

  • Rongzhen Yan

    (New York University Langone Medical Center)

  • Luping Yin

    (New York University Langone Medical Center)

  • Regina M. Sullivan

    (New York University Langone Medical Center)

  • Dayu Lin

    (New York University Langone Medical Center
    New York University Langone Medical Center
    New York University)

Abstract

In many species, including mice, female animals show markedly different pup-directed behaviours based on their reproductive state1,2. Naive wild female mice often kill pups, while lactating female mice are dedicated to pup caring3,4. The neural mechanisms that mediate infanticide and its switch to maternal behaviours during motherhood remain unclear. Here, on the basis of the hypothesis that maternal and infanticidal behaviours are supported by distinct and competing neural circuits5,6, we use the medial preoptic area (MPOA), a key site for maternal behaviours7–11, as a starting point and identify three MPOA-connected brain regions that drive differential negative pup-directed behaviours. Functional manipulation and in vivo recording reveal that oestrogen receptor α (ESR1)-expressing cells in the principal nucleus of the bed nucleus of stria terminalis (BNSTprESR1) are necessary, sufficient and naturally activated during infanticide in female mice. MPOAESR1 and BNSTprESR1 neurons form reciprocal inhibition to control the balance between positive and negative infant-directed behaviours. During motherhood, MPOAESR1 and BNSTprESR1 cells change their excitability in opposite directions, supporting a marked switch of female behaviours towards the young.

Suggested Citation

  • Long Mei & Rongzhen Yan & Luping Yin & Regina M. Sullivan & Dayu Lin, 2023. "Antagonistic circuits mediating infanticide and maternal care in female mice," Nature, Nature, vol. 618(7967), pages 1006-1016, June.
  • Handle: RePEc:nat:nature:v:618:y:2023:i:7967:d:10.1038_s41586-023-06147-9
    DOI: 10.1038/s41586-023-06147-9
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    Cited by:

    1. Can Tao & Guang-Wei Zhang & Wen-Jian Sun & Junxiang J. Huang & Li I. Zhang & Huizhong Whit Tao, 2024. "Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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