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Adeno-associated virus type 2 in US children with acute severe hepatitis

Author

Listed:
  • Venice Servellita

    (University of California, San Francisco)

  • Alicia Sotomayor Gonzalez

    (University of California, San Francisco)

  • Daryl M. Lamson

    (David Axelrod Institute)

  • Abiodun Foresythe

    (University of California, San Francisco)

  • Hee Jae Huh

    (University of California, San Francisco
    Sungkyunkwan University School of Medicine)

  • Adam L. Bazinet

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Nicholas H. Bergman

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Robert L. Bull

    (Federal Bureau of Investigation Laboratory Division/Scientific Response and Analysis Unit)

  • Karla Y. Garcia

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Jennifer S. Goodrich

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Sean P. Lovett

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Kisha Parker

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Diana Radune

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • April Hatada

    (California Department of Public Health)

  • Chao-Yang Pan

    (California Department of Public Health)

  • Kyle Rizzo

    (California Department of Public Health)

  • J. Bradford Bertumen

    (California Department of Public Health
    Centers for Disease Control and Prevention)

  • Christina Morales

    (California Department of Public Health)

  • Paul E. Oluniyi

    (University of California, San Francisco)

  • Jenny Nguyen

    (University of California, San Francisco)

  • Jessica Tan

    (University of California, San Francisco)

  • Doug Stryke

    (University of California, San Francisco)

  • Rayah Jaber

    (Florida Department of Health)

  • Matthew T. Leslie

    (Illinois Department of Public Health)

  • Zin Lyons

    (North Carolina Department of Health and Human Services)

  • Hayden D. Hedman

    (Centers for Disease Control and Prevention
    South Dakota Department of Health)

  • Umesh Parashar

    (Centers for Disease Control and Prevention)

  • Maureen Sullivan

    (Association for Public Health Laboratories)

  • Kelly Wroblewski

    (Association for Public Health Laboratories)

  • M. Steven Oberste

    (Centers for Disease Control and Prevention)

  • Jacqueline E. Tate

    (Centers for Disease Control and Prevention)

  • Julia M. Baker

    (Centers for Disease Control and Prevention)

  • David Sugerman

    (Centers for Disease Control and Prevention)

  • Caelin Potts

    (Centers for Disease Control and Prevention)

  • Xiaoyan Lu

    (Centers for Disease Control and Prevention)

  • Preeti Chhabra

    (Centers for Disease Control and Prevention)

  • L. Amanda Ingram

    (Alabama Department of Public Health)

  • Henry Shiau

    (University of Alabama at Birmingham)

  • William Britt

    (University of Alabama at Birmingham)

  • Luz Helena Gutierrez Sanchez

    (University of Alabama at Birmingham)

  • Caroline Ciric

    (Emory University School of Medicine and Children’s Healthcare of Atlanta)

  • Christina A. Rostad

    (Emory University School of Medicine and Children’s Healthcare of Atlanta)

  • Jan Vinjé

    (Centers for Disease Control and Prevention)

  • Hannah L. Kirking

    (Centers for Disease Control and Prevention)

  • Debra A. Wadford

    (California Department of Public Health)

  • R. Taylor Raborn

    (National Biodefense Analysis and Countermeasures Center (NBACC))

  • Kirsten George

    (David Axelrod Institute
    University at Albany, SUNY)

  • Charles Y. Chiu

    (University of California, San Francisco
    University of California, San Francisco
    Chan-Zuckerberg Biohub)

Abstract

As of August 2022, clusters of acute severe hepatitis of unknown aetiology in children have been reported from 35 countries, including the USA1,2. Previous studies have found human adenoviruses (HAdVs) in the blood from patients in Europe and the USA3–7, although it is unclear whether this virus is causative. Here we used PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing to analyse samples from 16 HAdV-positive cases from 1 October 2021 to 22 May 2022, in parallel with 113 controls. In blood from 14 cases, adeno-associated virus type 2 (AAV2) sequences were detected in 93% (13 of 14), compared to 4 (3.5%) of 113 controls (P

Suggested Citation

  • Venice Servellita & Alicia Sotomayor Gonzalez & Daryl M. Lamson & Abiodun Foresythe & Hee Jae Huh & Adam L. Bazinet & Nicholas H. Bergman & Robert L. Bull & Karla Y. Garcia & Jennifer S. Goodrich & Se, 2023. "Adeno-associated virus type 2 in US children with acute severe hepatitis," Nature, Nature, vol. 617(7961), pages 574-580, May.
    • Handle: RePEc:nat:nature:v:617:y:2023:i:7961:d:10.1038_s41586-023-05949-1
    DOI: 10.1038/s41586-023-05949-1
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    Cited by:

    1. Jessica Karielle Tan & Venice Servellita & Doug Stryke & Emily Kelly & Jessica Streithorst & Nanami Sumimoto & Abiodun Foresythe & Hee Jae Huh & Jenny Nguyen & Miriam Oseguera & Noah Brazer & Jack Tan, 2024. "Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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