IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v616y2023i7958d10.1038_s41586-023-05857-4.html
   My bibliography  Save this article

Clonal haematopoiesis and risk of chronic liver disease

Author

Listed:
  • Waihay J. Wong

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Connor Emdin

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital)

  • Alexander G. Bick

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Vanderbilt University Medical Center)

  • Seyedeh M. Zekavat

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Yale University School of Medicine
    Harvard Medical School)

  • Abhishek Niroula

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Lund University)

  • James P. Pirruccello

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital
    University of California San Francisco)

  • Laura Dichtel

    (Massachusetts General Hospital
    Harvard Medical School)

  • Gabriel Griffin

    (Brigham and Women’s Hospital
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Dana-Farber Cancer Institute)

  • Md Mesbah Uddin

    (Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Christopher J. Gibson

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Veronica Kovalcik

    (Dana-Farber Cancer Institute)

  • Amy E. Lin

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Brigham and Women’s Hospital)

  • Marie E. McConkey

    (Dana-Farber Cancer Institute)

  • Amelie Vromman

    (Brigham and Women’s Hospital)

  • Rob S. Sellar

    (Dana-Farber Cancer Institute
    UCL Cancer Institute)

  • Peter G. Kim

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Mridul Agrawal

    (Dana-Farber Cancer Institute)

  • Joshua Weinstock

    (University of Michigan School of Public Health)

  • Michelle T. Long

    (Boston University School of Medicine)

  • Bing Yu

    (University of Texas Health Science Center at Houston
    The University of Texas Health Science Center at Houston)

  • Rajarshi Banerjee

    (Perspectum Ltd)

  • Rowan C. Nicholls

    (Perspectum Ltd)

  • Andrea Dennis

    (Perspectum Ltd)

  • Matt Kelly

    (Perspectum Ltd)

  • Po-Ru Loh

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Harvard Medical School
    Brigham and Women’s Hospital)

  • Steve McCarroll

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Harvard Medical School)

  • Eric Boerwinkle

    (The University of Texas Health Science Center at Houston
    Baylor College of Medicine)

  • Ramachandran S. Vasan

    (The University of Texas School of Public Health San Antonio
    Framingham Heart Study of the NHLBI and Boston University School of Medicine
    The University of Texas Health Science Center)

  • Siddhartha Jaiswal

    (Stanford University School of Medicine)

  • Andrew D. Johnson

    (National Heart, Lung, and Blood Institute)

  • Raymond T. Chung

    (Harvard Medical School
    Massachusetts General Hospital)

  • Kathleen Corey

    (Harvard Medical School
    Massachusetts General Hospital)

  • Daniel Levy

    (Framingham Heart Study of the NHLBI and Boston University School of Medicine
    National Institutes of Health)

  • Christie Ballantyne

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Benjamin L. Ebert

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Pradeep Natarajan

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School)

Abstract

Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P

Suggested Citation

  • Waihay J. Wong & Connor Emdin & Alexander G. Bick & Seyedeh M. Zekavat & Abhishek Niroula & James P. Pirruccello & Laura Dichtel & Gabriel Griffin & Md Mesbah Uddin & Christopher J. Gibson & Veronica , 2023. "Clonal haematopoiesis and risk of chronic liver disease," Nature, Nature, vol. 616(7958), pages 747-754, April.
  • Handle: RePEc:nat:nature:v:616:y:2023:i:7958:d:10.1038_s41586-023-05857-4
    DOI: 10.1038/s41586-023-05857-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-023-05857-4
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-023-05857-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yash Pershad & Taralynn Mack & Hannah Poisner & Yasminka A. Jakubek & Adrienne M. Stilp & Braxton D. Mitchell & Joshua P. Lewis & Eric Boerwinkle & Ruth J. F. Loos & Nathalie Chami & Zhe Wang & Kathle, 2024. "Determinants of mosaic chromosomal alteration fitness," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:616:y:2023:i:7958:d:10.1038_s41586-023-05857-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.