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Clonal haematopoiesis and risk of chronic liver disease

Author

Listed:
  • Waihay J. Wong

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital
    Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Connor Emdin

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital)

  • Alexander G. Bick

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Vanderbilt University Medical Center)

  • Seyedeh M. Zekavat

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Yale University School of Medicine
    Harvard Medical School)

  • Abhishek Niroula

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Lund University)

  • James P. Pirruccello

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital
    University of California San Francisco)

  • Laura Dichtel

    (Massachusetts General Hospital
    Harvard Medical School)

  • Gabriel Griffin

    (Brigham and Women’s Hospital
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Dana-Farber Cancer Institute)

  • Md Mesbah Uddin

    (Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Christopher J. Gibson

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Veronica Kovalcik

    (Dana-Farber Cancer Institute)

  • Amy E. Lin

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Brigham and Women’s Hospital)

  • Marie E. McConkey

    (Dana-Farber Cancer Institute)

  • Amelie Vromman

    (Brigham and Women’s Hospital)

  • Rob S. Sellar

    (Dana-Farber Cancer Institute
    UCL Cancer Institute)

  • Peter G. Kim

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University)

  • Mridul Agrawal

    (Dana-Farber Cancer Institute)

  • Joshua Weinstock

    (University of Michigan School of Public Health)

  • Michelle T. Long

    (Boston University School of Medicine)

  • Bing Yu

    (University of Texas Health Science Center at Houston
    The University of Texas Health Science Center at Houston)

  • Rajarshi Banerjee

    (Perspectum Ltd)

  • Rowan C. Nicholls

    (Perspectum Ltd)

  • Andrea Dennis

    (Perspectum Ltd)

  • Matt Kelly

    (Perspectum Ltd)

  • Po-Ru Loh

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Harvard Medical School
    Brigham and Women’s Hospital)

  • Steve McCarroll

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Harvard Medical School)

  • Eric Boerwinkle

    (The University of Texas Health Science Center at Houston
    Baylor College of Medicine)

  • Ramachandran S. Vasan

    (The University of Texas School of Public Health San Antonio
    Framingham Heart Study of the NHLBI and Boston University School of Medicine
    The University of Texas Health Science Center)

  • Siddhartha Jaiswal

    (Stanford University School of Medicine)

  • Andrew D. Johnson

    (National Heart, Lung, and Blood Institute)

  • Raymond T. Chung

    (Harvard Medical School
    Massachusetts General Hospital)

  • Kathleen Corey

    (Harvard Medical School
    Massachusetts General Hospital)

  • Daniel Levy

    (Framingham Heart Study of the NHLBI and Boston University School of Medicine
    National Institutes of Health)

  • Christie Ballantyne

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Benjamin L. Ebert

    (Dana-Farber Cancer Institute
    Broad Institute of Massachusetts Institute of Technology and Harvard University
    Harvard Medical School
    Dana-Farber Cancer Institute)

  • Pradeep Natarajan

    (Broad Institute of Massachusetts Institute of Technology and Harvard University
    Massachusetts General Hospital
    Cardiovascular Research Center, Massachusetts General Hospital
    Harvard Medical School)

Abstract

Chronic liver disease is a major public health burden worldwide1. Although different aetiologies and mechanisms of liver injury exist, progression of chronic liver disease follows a common pathway of liver inflammation, injury and fibrosis2. Here we examined the association between clonal haematopoiesis of indeterminate potential (CHIP) and chronic liver disease in 214,563 individuals from 4 independent cohorts with whole-exome sequencing data (Framingham Heart Study, Atherosclerosis Risk in Communities Study, UK Biobank and Mass General Brigham Biobank). CHIP was associated with an increased risk of prevalent and incident chronic liver disease (odds ratio = 2.01, 95% confidence interval (95% CI) [1.46, 2.79]; P

Suggested Citation

  • Waihay J. Wong & Connor Emdin & Alexander G. Bick & Seyedeh M. Zekavat & Abhishek Niroula & James P. Pirruccello & Laura Dichtel & Gabriel Griffin & Md Mesbah Uddin & Christopher J. Gibson & Veronica , 2023. "Clonal haematopoiesis and risk of chronic liver disease," Nature, Nature, vol. 616(7958), pages 747-754, April.
    • Handle: RePEc:nat:nature:v:616:y:2023:i:7958:d:10.1038_s41586-023-05857-4
    DOI: 10.1038/s41586-023-05857-4
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    Cited by:

    1. Yash Pershad & Taralynn Mack & Hannah Poisner & Yasminka A. Jakubek & Adrienne M. Stilp & Braxton D. Mitchell & Joshua P. Lewis & Eric Boerwinkle & Ruth J. F. Loos & Nathalie Chami & Zhe Wang & Kathle, 2024. "Determinants of mosaic chromosomal alteration fitness," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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