IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v606y2022i7915d10.1038_s41586-022-04804-z.html
   My bibliography  Save this article

Lifelong multilineage contribution by embryonic-born blood progenitors

Author

Listed:
  • Sachin H. Patel

    (Boston Children’s Hospital)

  • Constantina Christodoulou

    (Boston Children’s Hospital)

  • Caleb Weinreb

    (Harvard Medical School)

  • Qi Yu

    (Boston Children’s Hospital)

  • Edroaldo Lummertz da Rocha

    (Federal University of Santa Catarina)

  • Brian J. Pepe-Mooney

    (Boston Children’s Hospital)

  • Sarah Bowling

    (Boston Children’s Hospital)

  • Li Li

    (Boston Children’s Hospital)

  • Fernando G. Osorio

    (Boston Children’s Hospital)

  • George Q. Daley

    (Boston Children’s Hospital
    Boston Children’s Hospital and Dana Farber Cancer Institute
    Harvard Medical School)

  • Fernando D. Camargo

    (Boston Children’s Hospital
    Harvard University)

Abstract

Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through a process known as the endothelial-to-haematopoietic transition (EHT)1–4. This process generates hundreds of blood progenitors, of which a fraction go on to become definitive HSCs. It is generally thought that most adult blood is derived from those HSCs, but to what extent other progenitors contribute to adult haematopoiesis is not known. Here we use in situ barcoding and classical fate mapping to assess the developmental and clonal origins of adult blood in mice. Our analysis uncovers an early wave of progenitor specification—independent of traditional HSCs—that begins soon after EHT. These embryonic multipotent progenitors (eMPPs) predominantly drive haematopoiesis in the young adult, have a decreasing yet lifelong contribution over time and are the predominant source of lymphoid output. Putative eMPPs are specified within intra-arterial haematopoietic clusters and represent one fate of the earliest haematopoietic progenitors. Altogether, our results reveal functional heterogeneity during the definitive wave that leads to distinct sources of adult blood.

Suggested Citation

  • Sachin H. Patel & Constantina Christodoulou & Caleb Weinreb & Qi Yu & Edroaldo Lummertz da Rocha & Brian J. Pepe-Mooney & Sarah Bowling & Li Li & Fernando G. Osorio & George Q. Daley & Fernando D. Cam, 2022. "Lifelong multilineage contribution by embryonic-born blood progenitors," Nature, Nature, vol. 606(7915), pages 747-753, June.
    • Handle: RePEc:nat:nature:v:606:y:2022:i:7915:d:10.1038_s41586-022-04804-z
    DOI: 10.1038/s41586-022-04804-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-022-04804-z
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-022-04804-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Roshana Thambyrajah & Maria Maqueda & Muhammad Zaki Fadlullah & Martin Proffitt & Wen Hao Neo & Yolanda Guillén & Marta Casado-Pelaez & Patricia Herrero-Molinero & Carla Brujas & Noemi Castelluccio & , 2024. "IκBα controls dormancy in hematopoietic stem cells via retinoic acid during embryonic development," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:606:y:2022:i:7915:d:10.1038_s41586-022-04804-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.