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Spatial maps in piriform cortex during olfactory navigation

Author

Listed:
  • Cindy Poo

    (Champalimaud Foundation)

  • Gautam Agarwal

    (The Claremont Colleges)

  • Niccolò Bonacchi

    (Champalimaud Foundation)

  • Zachary F. Mainen

    (Champalimaud Foundation)

Abstract

Odours are a fundamental part of the sensory environment used by animals to guide behaviours such as foraging and navigation1,2. Primary olfactory (piriform) cortex is thought to be the main cortical region for encoding odour identity3–8. Here, using neural ensemble recordings in freely moving rats performing an odour-cued spatial choice task, we show that posterior piriform cortex neurons carry a robust spatial representation of the environment. Piriform spatial representations have features of a learned cognitive map, being most prominent near odour ports, stable across behavioural contexts and independent of olfactory drive or reward availability. The accuracy of spatial information carried by individual piriform neurons was predicted by the strength of their functional coupling to the hippocampal theta rhythm. Ensembles of piriform neurons concurrently represented odour identity as well as spatial locations of animals, forming an odour–place map. Our results reveal a function for piriform cortex in spatial cognition and suggest that it is well-suited to form odour–place associations and guide olfactory-cued spatial navigation.

Suggested Citation

  • Cindy Poo & Gautam Agarwal & Niccolò Bonacchi & Zachary F. Mainen, 2022. "Spatial maps in piriform cortex during olfactory navigation," Nature, Nature, vol. 601(7894), pages 595-599, January.
    • Handle: RePEc:nat:nature:v:601:y:2022:i:7894:d:10.1038_s41586-021-04242-3
    DOI: 10.1038/s41586-021-04242-3
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    Cited by:

    1. Joana Mendes Duarte & Robin Nguyen & Marios Kyprou & Kaizhen Li & Anastasija Milentijevic & Carlo Cerquetella & Thomas Forro & Stéphane Ciocchi, 2024. "Hippocampal contextualization of social rewards in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Joseph D. Zak & Gautam Reddy & Vaibhav Konanur & Venkatesh N. Murthy, 2024. "Distinct information conveyed to the olfactory bulb by feedforward input from the nose and feedback from the cortex," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Samuel K. H. Sy & Danny C. W. Chan & Roy C. H. Chan & Jing Lyu & Zhongqi Li & Kenneth K. Y. Wong & Chung Hang Jonathan Choi & Vincent C. T. Mok & Hei-Ming Lai & Owen Randlett & Yu Hu & Ho Ko, 2023. "An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation in larval zebrafish," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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