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Single-cell delineation of lineage and genetic identity in the mouse brain

Author

Listed:
  • Rachel C. Bandler

    (Max Planck Institute of Neurobiology
    Langone Medical Center
    Stanley Center for Psychiatric Research)

  • Ilaria Vitali

    (Max Planck Institute of Neurobiology)

  • Ryan N. Delgado

    (University of California
    University of California
    University of California)

  • May C. Ho

    (Max Planck Institute of Neurobiology)

  • Elena Dvoretskova

    (Max Planck Institute of Neurobiology)

  • Josue S. Ibarra Molinas

    (Max Planck Institute of Neurobiology)

  • Paul W. Frazel

    (Langone Medical Center)

  • Maesoumeh Mohammadkhani

    (Langone Medical Center)

  • Robert Machold

    (Langone Medical Center)

  • Sophia Maedler

    (Max Planck Institute of Biochemistry)

  • Shane A. Liddelow

    (Langone Medical Center
    New York University Grossman School of Medicine
    New York University Grossman School of Medicine)

  • Tomasz J. Nowakowski

    (University of California
    University of California
    University of California)

  • Gord Fishell

    (Stanley Center for Psychiatric Research
    Harvard Medical School, Department of Neurobiology)

  • Christian Mayer

    (Max Planck Institute of Neurobiology)

Abstract

During neurogenesis, mitotic progenitor cells lining the ventricles of the embryonic mouse brain undergo their final rounds of cell division, giving rise to a wide spectrum of postmitotic neurons and glia1,2. The link between developmental lineage and cell-type diversity remains an open question. Here we used massively parallel tagging of progenitors to track clonal relationships and transcriptomic signatures during mouse forebrain development. We quantified clonal divergence and convergence across all major cell classes postnatally, and found diverse types of GABAergic neuron that share a common lineage. Divergence of GABAergic clones occurred during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.

Suggested Citation

  • Rachel C. Bandler & Ilaria Vitali & Ryan N. Delgado & May C. Ho & Elena Dvoretskova & Josue S. Ibarra Molinas & Paul W. Frazel & Maesoumeh Mohammadkhani & Robert Machold & Sophia Maedler & Shane A. Li, 2022. "Single-cell delineation of lineage and genetic identity in the mouse brain," Nature, Nature, vol. 601(7893), pages 404-409, January.
    • Handle: RePEc:nat:nature:v:601:y:2022:i:7893:d:10.1038_s41586-021-04237-0
    DOI: 10.1038/s41586-021-04237-0
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    Cited by:

    1. Zeinab Asgarian & Marcio Guiomar Oliveira & Agata Stryjewska & Ioannis Maragkos & Anna Noren Rubin & Lorenza Magno & Vassilis Pachnis & Mohammadmersad Ghorbani & Scott Wayne Hiebert & Myrto Denaxa & N, 2022. "MTG8 interacts with LHX6 to specify cortical interneuron subtype identity," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ziqi Zhang & Haoran Sun & Ragunathan Mariappan & Xi Chen & Xinyu Chen & Mika S. Jain & Mirjana Efremova & Sarah A. Teichmann & Vaibhav Rajan & Xiuwei Zhang, 2023. "scMoMaT jointly performs single cell mosaic integration and multi-modal bio-marker detection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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