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NLRs guard metabolism to coordinate pattern- and effector-triggered immunity

Author

Listed:
  • Keran Zhai

    (Chinese Academy of Sciences)

  • Di Liang

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Helin Li

    (Chinese Academy of Sciences
    Henan University)

  • Fangyuan Jiao

    (Chinese Academy of Sciences
    Shanghai Tech University)

  • Bingxiao Yan

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Jing Liu

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Ziyao Lei

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Li Huang

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Xiangyu Gong

    (Chinese Academy of Sciences
    University of the Chinese Academy of Sciences)

  • Xin Wang

    (Chinese Academy of Sciences)

  • Jiashun Miao

    (Chinese Academy of Sciences)

  • Yichuan Wang

    (Institute of Plant and Food Science, Southern University of Science and Technology)

  • Ji-Yun Liu

    (Chinese Academy of Sciences)

  • Lin Zhang

    (Yangzhou University)

  • Ertao Wang

    (Chinese Academy of Sciences)

  • Yiwen Deng

    (Chinese Academy of Sciences)

  • Chi-Kuang Wen

    (Chinese Academy of Sciences)

  • Hongwei Guo

    (Institute of Plant and Food Science, Southern University of Science and Technology)

  • Bin Han

    (Chinese Academy of Sciences)

  • Zuhua He

    (Chinese Academy of Sciences
    Shanghai Tech University)

Abstract

Pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) in plants enable them to respond to pathogens by activating the production of defence metabolites that orchestrate immune responses1–4. How the production of defence metabolites is promoted by immune receptors and coordinated with broad-spectrum resistance remains elusive. Here we identify the deubiquitinase PICI1 as an immunity hub for PTI and ETI in rice (Oryza sativa). PICI1 deubiquitinates and stabilizes methionine synthetases to activate methionine-mediated immunity principally through biosynthesis of the phytohormone ethylene. PICI1 is targeted for degradation by blast fungal effectors, including AvrPi9, to dampen PTI. Nucleotide-binding domain, leucine-rich-repeat-containing receptors (NLRs) in the plant immune system, such as PigmR, protect PICI1 from effector-mediated degradation to reboot the methionine–ethylene cascade. Natural variation in the PICI1 gene contributes to divergence in basal blast resistance between the rice subspecies indica and japonica. Thus, NLRs govern an arms race with effectors, using a competitive mode that hinges on a critical defence metabolic pathway to synchronize PTI with ETI and ensure broad-spectrum resistance.

Suggested Citation

  • Keran Zhai & Di Liang & Helin Li & Fangyuan Jiao & Bingxiao Yan & Jing Liu & Ziyao Lei & Li Huang & Xiangyu Gong & Xin Wang & Jiashun Miao & Yichuan Wang & Ji-Yun Liu & Lin Zhang & Ertao Wang & Yiwen , 2022. "NLRs guard metabolism to coordinate pattern- and effector-triggered immunity," Nature, Nature, vol. 601(7892), pages 245-251, January.
    • Handle: RePEc:nat:nature:v:601:y:2022:i:7892:d:10.1038_s41586-021-04219-2
    DOI: 10.1038/s41586-021-04219-2
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    Cited by:

    1. Xueting Gu & Fuyan Si & Zhengxiang Feng & Shunjie Li & Di Liang & Pei Yang & Chao Yang & Bin Yan & Jun Tang & Yu Yang & Tai Li & Lin Li & Jinling Zhou & Ji Li & Lili Feng & Ji-Yun Liu & Yuanzhu Yang &, 2023. "The OsSGS3-tasiRNA-OsARF3 module orchestrates abiotic-biotic stress response trade-off in rice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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