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A roadmap for the Human Developmental Cell Atlas

Author

Listed:
  • Muzlifah Haniffa

    (Newcastle University
    Wellcome Sanger Institute
    Newcastle Hospitals NHS Foundation Trust)

  • Deanne Taylor

    (The Children’s Hospital of Philadelphia
    University of Pennsylvania Perelman School of Medicine)

  • Sten Linnarsson

    (Karolinska Institutet)

  • Bruce J. Aronow

    (Cincinnati Children’s Hospital Medical Centre)

  • Gary D. Bader

    (University of Toronto)

  • Roger A. Barker

    (University of Cambridge
    University of Cambridge)

  • Pablo G. Camara

    (University of Pennsylvania Perelman School of Medicine)

  • J. Gray Camp

    (University of Basel)

  • Alain Chédotal

    (INSERM, CNRS, Institut de la Vision, Sorbonne Université)

  • Andrew Copp

    (UCL Great Ormond Street Institute of Child Health)

  • Heather C. Etchevers

    (MMG, INSERM, U1251, Aix Marseille Université)

  • Paolo Giacobini

    (Laboratory of Development and Plasticity of the Neuroendocrine Brain, Inserm, CHU Lille, Lille Neuroscience and Cognition, UMR-S 1172, Université Lille)

  • Berthold Göttgens

    (University of Cambridge
    University of Cambridge)

  • Guoji Guo

    (Zhejiang University School of Medicine)

  • Ania Hupalowska

    (Klarman Cell Observatory, Broad Institute of Harvard and MIT)

  • Kylie R. James

    (Wellcome Sanger Institute)

  • Emily Kirby

    (McGill University)

  • Arnold Kriegstein

    (University of California San Francisco (UCSF))

  • Joakim Lundeberg

    (Science for Life Laboratory, KTH Royal Institute of Technology)

  • John C. Marioni

    (University of Cambridge)

  • Kerstin B. Meyer

    (Wellcome Sanger Institute)

  • Kathy K. Niakan

    (Francis Crick Institute
    University of Cambridge)

  • Mats Nilsson

    (Stockholm University)

  • Bayanne Olabi

    (Newcastle University)

  • Dana Pe’er

    (Memorial Sloan Kettering Cancer Center)

  • Aviv Regev

    (Klarman Cell Observatory, Broad Institute of Harvard and MIT
    Massachusetts Institute of Technology
    Genentech)

  • Jennifer Rood

    (Klarman Cell Observatory, Broad Institute of Harvard and MIT)

  • Orit Rozenblatt-Rosen

    (Klarman Cell Observatory, Broad Institute of Harvard and MIT
    Genentech)

  • Rahul Satija

    (New York University)

  • Sarah A. Teichmann

    (Wellcome Sanger Institute
    University of Cambridge)

  • Barbara Treutlein

    (Eidgenössische Technische Hochschule (ETH) Zurich)

  • Roser Vento-Tormo

    (Wellcome Sanger Institute)

  • Simone Webb

    (Newcastle University)

Abstract

The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.

Suggested Citation

  • Muzlifah Haniffa & Deanne Taylor & Sten Linnarsson & Bruce J. Aronow & Gary D. Bader & Roger A. Barker & Pablo G. Camara & J. Gray Camp & Alain Chédotal & Andrew Copp & Heather C. Etchevers & Paolo Gi, 2021. "A roadmap for the Human Developmental Cell Atlas," Nature, Nature, vol. 597(7875), pages 196-205, September.
    • Handle: RePEc:nat:nature:v:597:y:2021:i:7875:d:10.1038_s41586-021-03620-1
    DOI: 10.1038/s41586-021-03620-1
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    Citations

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    Cited by:

    1. Emily Kirby & Alexander Bernier & Roderic Guigó & Barbara Wold & Fabiana Arzuaga & Mayumi Kusunose & Ma’n Zawati & Bartha M. Knoppers, 2024. "Data sharing ethics toolkit: The Human Cell Atlas," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    2. Sanem Sariyar & Alexandros Sountoulidis & Jan Niklas Hansen & Sergio Marco Salas & Mariya Mardamshina & Anna Martinez Casals & Frederic Ballllosera Navarro & Zaneta Andrusivova & Xiaofei Li & Paulo Cz, 2024. "High-parametric protein maps reveal the spatial organization in early-developing human lung," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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