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Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans

Author

Listed:
  • Sanna Gudmundsson

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Boston Children’s Hospital)

  • Konrad J. Karczewski

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Laurent C. Francioli

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Grace Tiao

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Beryl B. Cummings

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Harvard Medical School)

  • Jessica Alföldi

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Qingbo Wang

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Harvard Medical School)

  • Ryan L. Collins

    (Broad Institute of MIT and Harvard
    Harvard Medical School
    Massachusetts General Hospital)

  • Kristen M. Laricchia

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Andrea Ganna

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Institute for Molecular Medicine Finland)

  • Daniel P. Birnbaum

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Laura D. Gauthier

    (Broad Institute of MIT and Harvard)

  • Harrison Brand

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Matthew Solomonson

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Nicholas A. Watts

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Daniel Rhodes

    (Queen Mary University of London and Barts Health NHS Trust)

  • Moriel Singer-Berk

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Eleina M. England

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Eleanor G. Seaby

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Jack A. Kosmicki

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Harvard Medical School)

  • Raymond K. Walters

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Katherine Tashman

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Yossi Farjoun

    (Broad Institute of MIT and Harvard)

  • Eric Banks

    (Broad Institute of MIT and Harvard)

  • Timothy Poterba

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Arcturus Wang

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Cotton Seed

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Nicola Whiffin

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Imperial College London
    Royal Brompton & Harefield Hospitals NHS Trust)

  • Jessica X. Chong

    (University of Washington)

  • Kaitlin E. Samocha

    (Wellcome Genome Campus)

  • Emma Pierce-Hoffman

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Zachary Zappala

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Vertex Pharmaceuticals Inc)

  • Anne H. O’Donnell-Luria

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Boston Children’s Hospital
    Harvard Medical School)

  • Eric Vallabh Minikel

    (Broad Institute of MIT and Harvard)

  • Ben Weisburd

    (Broad Institute of MIT and Harvard)

  • Monkol Lek

    (Yale School of Medicine)

  • James S. Ware

    (Broad Institute of MIT and Harvard
    Imperial College London
    Royal Brompton & Harefield Hospitals NHS Trust)

  • Christopher Vittal

    (Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Irina M. Armean

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital)

  • Louis Bergelson

    (Broad Institute of MIT and Harvard)

  • Kristian Cibulskis

    (Broad Institute of MIT and Harvard)

  • Kristen M. Connolly

    (Broad Institute of MIT and Harvard)

  • Miguel Covarrubias

    (Broad Institute of MIT and Harvard)

  • Stacey Donnelly

    (Broad Institute of MIT and Harvard)

  • Steven Ferriera

    (Broad Institute of MIT and Harvard)

  • Stacey Gabriel

    (Broad Institute of MIT and Harvard)

  • Jeff Gentry

    (Broad Institute of MIT and Harvard)

  • Namrata Gupta

    (Broad Institute of MIT and Harvard
    Broad Institute of MIT and Harvard)

  • Thibault Jeandet

    (Broad Institute of MIT and Harvard)

  • Diane Kaplan

    (Broad Institute of MIT and Harvard)

  • Christopher Llanwarne

    (Broad Institute of MIT and Harvard)

  • Ruchi Munshi

    (Broad Institute of MIT and Harvard)

  • Sam Novod

    (Broad Institute of MIT and Harvard)

  • Nikelle Petrillo

    (Broad Institute of MIT and Harvard)

  • David Roazen

    (Broad Institute of MIT and Harvard)

  • Valentin Ruano-Rubio

    (Broad Institute of MIT and Harvard)

  • Andrea Saltzman

    (Broad Institute of MIT and Harvard)

  • Molly Schleicher

    (Broad Institute of MIT and Harvard)

  • Jose Soto

    (Broad Institute of MIT and Harvard)

  • Kathleen Tibbetts

    (Broad Institute of MIT and Harvard)

  • Charlotte Tolonen

    (Broad Institute of MIT and Harvard)

  • Gordon Wade

    (Broad Institute of MIT and Harvard)

  • Michael E. Talkowski

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Harvard Medical School)

  • Benjamin M. Neale

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Broad Institute of MIT and Harvard)

  • Mark J. Daly

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Institute for Molecular Medicine Finland
    Broad Institute of MIT and Harvard)

  • Daniel G. MacArthur

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital
    Garvan Institute of Medical Research, and UNSW Sydney
    Murdoch Children’s Research Institute)

Abstract

No abstract is available for this item.

Suggested Citation

  • Sanna Gudmundsson & Konrad J. Karczewski & Laurent C. Francioli & Grace Tiao & Beryl B. Cummings & Jessica Alföldi & Qingbo Wang & Ryan L. Collins & Kristen M. Laricchia & Andrea Ganna & Daniel P. Bir, 2021. "Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans," Nature, Nature, vol. 597(7874), pages 3-4, September.
    • Handle: RePEc:nat:nature:v:597:y:2021:i:7874:d:10.1038_s41586-021-03758-y
    DOI: 10.1038/s41586-021-03758-y
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    Citations

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    Cited by:

    1. Atlas Khan & Ning Shang & Jordan G. Nestor & Chunhua Weng & George Hripcsak & Peter C. Harris & Ali G. Gharavi & Krzysztof Kiryluk, 2023. "Polygenic risk alters the penetrance of monogenic kidney disease," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Warren A. Cheung & Adam F. Johnson & William J. Rowell & Emily Farrow & Richard Hall & Ana S. A. Cohen & John C. Means & Tricia N. Zion & Daniel M. Portik & Christopher T. Saunders & Boryana Koseva & , 2023. "Direct haplotype-resolved 5-base HiFi sequencing for genome-wide profiling of hypermethylation outliers in a rare disease cohort," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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