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Strategic vision for improving human health at The Forefront of Genomics

Author

Listed:
  • Eric D. Green

    (National Institutes of Health)

  • Chris Gunter

    (National Institutes of Health)

  • Leslie G. Biesecker

    (National Institutes of Health)

  • Valentina Francesco

    (National Institutes of Health)

  • Carla L. Easter

    (National Institutes of Health)

  • Elise A. Feingold

    (National Institutes of Health)

  • Adam L. Felsenfeld

    (National Institutes of Health)

  • David J. Kaufman

    (National Institutes of Health)

  • Elaine A. Ostrander

    (National Institutes of Health)

  • William J. Pavan

    (National Institutes of Health)

  • Adam M. Phillippy

    (National Institutes of Health)

  • Anastasia L. Wise

    (National Institutes of Health)

  • Jyoti Gupta Dayal

    (National Institutes of Health)

  • Britny J. Kish

    (National Institutes of Health)

  • Allison Mandich

    (National Institutes of Health)

  • Christopher R. Wellington

    (National Institutes of Health)

  • Kris A. Wetterstrand

    (National Institutes of Health)

  • Sarah A. Bates

    (National Institutes of Health)

  • Darryl Leja

    (National Institutes of Health)

  • Susan Vasquez

    (National Institutes of Health)

  • William A. Gahl

    (National Institutes of Health)

  • Bettie J. Graham

    (National Institutes of Health)

  • Daniel L. Kastner

    (National Institutes of Health)

  • Paul Liu

    (National Institutes of Health)

  • Laura Lyman Rodriguez

    (National Institutes of Health)

  • Benjamin D. Solomon

    (National Institutes of Health)

  • Vence L. Bonham

    (National Institutes of Health)

  • Lawrence C. Brody

    (National Institutes of Health)

  • Carolyn M. Hutter

    (National Institutes of Health)

  • Teri A. Manolio

    (National Institutes of Health)

Abstract

Starting with the launch of the Human Genome Project three decades ago, and continuing after its completion in 2003, genomics has progressively come to have a central and catalytic role in basic and translational research. In addition, studies increasingly demonstrate how genomic information can be effectively used in clinical care. In the future, the anticipated advances in technology development, biological insights, and clinical applications (among others) will lead to more widespread integration of genomics into almost all areas of biomedical research, the adoption of genomics into mainstream medical and public-health practices, and an increasing relevance of genomics for everyday life. On behalf of the research community, the National Human Genome Research Institute recently completed a multi-year process of strategic engagement to identify future research priorities and opportunities in human genomics, with an emphasis on health applications. Here we describe the highest-priority elements envisioned for the cutting-edge of human genomics going forward—that is, at ‘The Forefront of Genomics’.

Suggested Citation

  • Eric D. Green & Chris Gunter & Leslie G. Biesecker & Valentina Francesco & Carla L. Easter & Elise A. Feingold & Adam L. Felsenfeld & David J. Kaufman & Elaine A. Ostrander & William J. Pavan & Adam M, 2020. "Strategic vision for improving human health at The Forefront of Genomics," Nature, Nature, vol. 586(7831), pages 683-692, October.
    • Handle: RePEc:nat:nature:v:586:y:2020:i:7831:d:10.1038_s41586-020-2817-4
    DOI: 10.1038/s41586-020-2817-4
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    Cited by:

    1. Matthew J. O’Neill & Tao Yang & Julie Laudeman & Maria E. Calandranis & M. Lorena Harvey & Joseph F. Solus & Dan M. Roden & Andrew M. Glazer, 2024. "ParSE-seq: a calibrated multiplexed assay to facilitate the clinical classification of putative splice-altering variants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Manuela Priolo & Marco Tartaglia, 2023. "The Right to Ask, the Need to Answer—When Patients Meet Research: How to Cope with Time," IJERPH, MDPI, vol. 20(5), pages 1-10, March.
    3. Lama AlAbdi & Sateesh Maddirevula & Hanan E. Shamseldin & Ebtissal Khouj & Rana Helaby & Halima Hamid & Aisha Almulhim & Mais O. Hashem & Firdous Abdulwahab & Omar Abouyousef & Mashael Alqahtani & Nor, 2023. "Diagnostic implications of pitfalls in causal variant identification based on 4577 molecularly characterized families," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    4. Amartya Mukhopadhyay & Jennifer Sumner & Lieng Hsi Ling & Raphael Hao Chong Quek & Andre Teck Huat Tan & Gim Gee Teng & Santhosh Kumar Seetharaman & Satya Pavan Kumar Gollamudi & Dean Ho & Mehul Motan, 2022. "Personalised Dosing Using the CURATE.AI Algorithm: Protocol for a Feasibility Study in Patients with Hypertension and Type II Diabetes Mellitus," IJERPH, MDPI, vol. 19(15), pages 1-11, July.
    5. Shim, Janet K. & Bentz, Michael & Vasquez, Emily & Jeske, Melanie & Saperstein, Aliya & Fullerton, Stephanie M. & Foti, Nicole & McMahon, Caitlin & Lee, Sandra Soo-Jin, 2022. "Strategies of inclusion: The tradeoffs of pursuing “baked in” diversity through place-based recruitment," Social Science & Medicine, Elsevier, vol. 306(C).

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