Author
Listed:
- Yinqing Li
(Tsinghua University
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Violeta G. Lopez-Huerta
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology
National Autonomous University of Mexico)
- Xian Adiconis
(Broad Institute of MIT and Harvard
Broad Institute of MIT and Harvard)
- Kirsten Levandowski
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Soonwook Choi
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Sean K. Simmons
(Broad Institute of MIT and Harvard
Broad Institute of MIT and Harvard)
- Mario A. Arias-Garcia
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology
National Autonomous University of Mexico)
- Baolin Guo
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Annie Y. Yao
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Timothy R. Blosser
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Ralf D. Wimmer
(Massachusetts Institute of Technology)
- Tomomi Aida
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Alexander Atamian
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Tina Naik
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Xuyun Sun
(Massachusetts Institute of Technology
Zhejiang University)
- Dasheng Bi
(Massachusetts Institute of Technology)
- Diya Malhotra
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Cynthia C. Hession
(Broad Institute of MIT and Harvard
Broad Institute of MIT and Harvard)
- Reut Shema
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Marcos Gomes
(Massachusetts Institute of Technology
Center for Neuroscience and Cell Biology
University of Coimbra, Institute for Interdisciplinary Research)
- Taibo Li
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Eunjin Hwang
(Korea Institute of Science and Technology)
- Alexandra Krol
(Massachusetts Institute of Technology)
- Monika Kowalczyk
(Broad Institute of MIT and Harvard)
- João Peça
(Center for Neuroscience and Cell Biology
University of Coimbra, Institute for Interdisciplinary Research
University of Coimbra, Department of Life Sciences)
- Gang Pan
(Zhejiang University)
- Michael M. Halassa
(Massachusetts Institute of Technology)
- Joshua Z. Levin
(Broad Institute of MIT and Harvard
Broad Institute of MIT and Harvard)
- Zhanyan Fu
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
- Guoping Feng
(Broad Institute of MIT and Harvard
Massachusetts Institute of Technology)
Abstract
The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates thalamocortical interactions that are critical for sensory processing, attention and cognition1–5. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders6–9. However, little is known about the organizational principles that underlie its divergent functions. Here we performed an integrative study linking single-cell molecular and electrophysiological features of the mouse TRN to connectivity and systems-level function. We found that cellular heterogeneity in the TRN is characterized by a transcriptomic gradient of two negatively correlated gene-expression profiles, each containing hundreds of genes. Neurons in the extremes of this transcriptomic gradient express mutually exclusive markers, exhibit core or shell-like anatomical structure and have distinct electrophysiological properties. The two TRN subpopulations make differential connections with the functionally distinct first-order and higher-order thalamic nuclei to form molecularly defined TRN–thalamus subnetworks. Selective perturbation of the two subnetworks in vivo revealed their differential role in regulating sleep. In sum, our study provides a comprehensive atlas of TRN neurons at single-cell resolution and links molecularly defined subnetworks to the functional organization of thalamocortical circuits.
Suggested Citation
Yinqing Li & Violeta G. Lopez-Huerta & Xian Adiconis & Kirsten Levandowski & Soonwook Choi & Sean K. Simmons & Mario A. Arias-Garcia & Baolin Guo & Annie Y. Yao & Timothy R. Blosser & Ralf D. Wimmer &, 2020.
"Distinct subnetworks of the thalamic reticular nucleus,"
Nature, Nature, vol. 583(7818), pages 819-824, July.
Handle:
RePEc:nat:nature:v:583:y:2020:i:7818:d:10.1038_s41586-020-2504-5
DOI: 10.1038/s41586-020-2504-5
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Citations
Citations are extracted by the
CitEc Project, subscribe to its
RSS feed for this item.
Cited by:
- Stuart Oldham & Gareth Ball, 2023.
"A phylogenetically-conserved axis of thalamocortical connectivity in the human brain,"
Nature Communications, Nature, vol. 14(1), pages 1-14, December.
- Ren, Xiufang & Lu, Yao & Luo, Jie & Zeng, Xudong, 2024.
"Response solutions for a kind of quasi-periodic forced neuron system,"
Chaos, Solitons & Fractals, Elsevier, vol. 179(C).
- Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024.
"Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus,"
Nature Communications, Nature, vol. 15(1), pages 1-17, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:583:y:2020:i:7818:d:10.1038_s41586-020-2504-5. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.