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Distinct subnetworks of the thalamic reticular nucleus

Author

Listed:
  • Yinqing Li

    (Tsinghua University
    Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Violeta G. Lopez-Huerta

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology
    National Autonomous University of Mexico)

  • Xian Adiconis

    (Broad Institute of MIT and Harvard
    Broad Institute of MIT and Harvard)

  • Kirsten Levandowski

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Soonwook Choi

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Sean K. Simmons

    (Broad Institute of MIT and Harvard
    Broad Institute of MIT and Harvard)

  • Mario A. Arias-Garcia

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology
    National Autonomous University of Mexico)

  • Baolin Guo

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Annie Y. Yao

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Timothy R. Blosser

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Ralf D. Wimmer

    (Massachusetts Institute of Technology)

  • Tomomi Aida

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Alexander Atamian

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Tina Naik

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Xuyun Sun

    (Massachusetts Institute of Technology
    Zhejiang University)

  • Dasheng Bi

    (Massachusetts Institute of Technology)

  • Diya Malhotra

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Cynthia C. Hession

    (Broad Institute of MIT and Harvard
    Broad Institute of MIT and Harvard)

  • Reut Shema

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Marcos Gomes

    (Massachusetts Institute of Technology
    Center for Neuroscience and Cell Biology
    University of Coimbra, Institute for Interdisciplinary Research)

  • Taibo Li

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Eunjin Hwang

    (Korea Institute of Science and Technology)

  • Alexandra Krol

    (Massachusetts Institute of Technology)

  • Monika Kowalczyk

    (Broad Institute of MIT and Harvard)

  • João Peça

    (Center for Neuroscience and Cell Biology
    University of Coimbra, Institute for Interdisciplinary Research
    University of Coimbra, Department of Life Sciences)

  • Gang Pan

    (Zhejiang University)

  • Michael M. Halassa

    (Massachusetts Institute of Technology)

  • Joshua Z. Levin

    (Broad Institute of MIT and Harvard
    Broad Institute of MIT and Harvard)

  • Zhanyan Fu

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

  • Guoping Feng

    (Broad Institute of MIT and Harvard
    Massachusetts Institute of Technology)

Abstract

The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates thalamocortical interactions that are critical for sensory processing, attention and cognition1–5. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders6–9. However, little is known about the organizational principles that underlie its divergent functions. Here we performed an integrative study linking single-cell molecular and electrophysiological features of the mouse TRN to connectivity and systems-level function. We found that cellular heterogeneity in the TRN is characterized by a transcriptomic gradient of two negatively correlated gene-expression profiles, each containing hundreds of genes. Neurons in the extremes of this transcriptomic gradient express mutually exclusive markers, exhibit core or shell-like anatomical structure and have distinct electrophysiological properties. The two TRN subpopulations make differential connections with the functionally distinct first-order and higher-order thalamic nuclei to form molecularly defined TRN–thalamus subnetworks. Selective perturbation of the two subnetworks in vivo revealed their differential role in regulating sleep. In sum, our study provides a comprehensive atlas of TRN neurons at single-cell resolution and links molecularly defined subnetworks to the functional organization of thalamocortical circuits.

Suggested Citation

  • Yinqing Li & Violeta G. Lopez-Huerta & Xian Adiconis & Kirsten Levandowski & Soonwook Choi & Sean K. Simmons & Mario A. Arias-Garcia & Baolin Guo & Annie Y. Yao & Timothy R. Blosser & Ralf D. Wimmer &, 2020. "Distinct subnetworks of the thalamic reticular nucleus," Nature, Nature, vol. 583(7818), pages 819-824, July.
  • Handle: RePEc:nat:nature:v:583:y:2020:i:7818:d:10.1038_s41586-020-2504-5
    DOI: 10.1038/s41586-020-2504-5
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    Citations

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    Cited by:

    1. Stuart Oldham & Gareth Ball, 2023. "A phylogenetically-conserved axis of thalamocortical connectivity in the human brain," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Ren, Xiufang & Lu, Yao & Luo, Jie & Zeng, Xudong, 2024. "Response solutions for a kind of quasi-periodic forced neuron system," Chaos, Solitons & Fractals, Elsevier, vol. 179(C).
    3. Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024. "Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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