Author
Listed:
- Frido Welker
(University of Copenhagen)
- Jazmín Ramos-Madrigal
(University of Copenhagen)
- Petra Gutenbrunner
(Max Planck Institute of Biochemistry)
- Meaghan Mackie
(University of Copenhagen
University of Copenhagen)
- Shivani Tiwary
(Max Planck Institute of Biochemistry)
- Rosa Rakownikow Jersie-Christensen
(University of Copenhagen)
- Cristina Chiva
(Barcelona Institute of Science and Technology
University Pompeu Fabra)
- Marc R. Dickinson
(University of York)
- Martin Kuhlwilm
(University Pompeu Fabra)
- Marc Manuel
(University Pompeu Fabra)
- Pere Gelabert
(University Pompeu Fabra)
- María Martinón-Torres
(Centro Nacional de Investigación sobre la Evolución Humana (CENIEH)
University College London)
- Ann Margvelashvili
(Georgian National Museum)
- Juan Luis Arsuaga
(Centro Mixto UCM-ISCIII de Evolución y Comportamiento Humanos
Departamento de Paleontología, Facultad de Ciencias Geológicas, Universidad Complutense de Madrid)
- Eudald Carbonell
(Departamento d’Història i Història de l’Art, Universidad Rovira i Virgili
Institut Català de Paleoecologia Humana i Evolució Social (IPHES))
- Tomas Marques-Bonet
(Barcelona Institute of Science and Technology
University Pompeu Fabra
Catalan Institution of Research and Advanced Studies (ICREA)
Institut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona)
- Kirsty Penkman
(University of York)
- Eduard Sabidó
(Barcelona Institute of Science and Technology
University Pompeu Fabra)
- Jürgen Cox
(Max Planck Institute of Biochemistry)
- Jesper V. Olsen
(University of Copenhagen)
- David Lordkipanidze
(Georgian National Museum
Tbilisi State University)
- Fernando Racimo
(University of Copenhagen)
- Carles Lalueza-Fox
(University Pompeu Fabra)
- José María Bermúdez de Castro
(Centro Nacional de Investigación sobre la Evolución Humana (CENIEH)
University College London)
- Eske Willerslev
(University of Copenhagen
University of Cambridge
Wellcome Sanger Institute
University of Southern Denmark)
- Enrico Cappellini
(University of Copenhagen)
Abstract
The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo sapiens, are highly debated1–5. For the oldest remains, the molecular study of these relationships is hindered by the degradation of ancient DNA. However, recent research has demonstrated that the analysis of ancient proteins can address this challenge6–8. Here we present the dental enamel proteomes of H. antecessor from Atapuerca (Spain)9,10 and Homo erectus from Dmanisi (Georgia)1, two key fossil assemblages that have a central role in models of Pleistocene hominin morphology, dispersal and divergence. We provide evidence that H. antecessor is a close sister lineage to subsequent Middle and Late Pleistocene hominins, including modern humans, Neanderthals and Denisovans. This placement implies that the modern-like face of H. antecessor—that is, similar to that of modern humans—may have a considerably deep ancestry in the genus Homo, and that the cranial morphology of Neanderthals represents a derived form. By recovering AMELY-specific peptide sequences, we also conclude that the H. antecessor molar fragment from Atapuerca that we analysed belonged to a male individual. Finally, these H. antecessor and H. erectus fossils preserve evidence of enamel proteome phosphorylation and proteolytic digestion that occurred in vivo during tooth formation. Our results provide important insights into the evolutionary relationships between H. antecessor and other hominin groups, and pave the way for future studies using enamel proteomes to investigate hominin biology across the existence of the genus Homo.
Suggested Citation
Frido Welker & Jazmín Ramos-Madrigal & Petra Gutenbrunner & Meaghan Mackie & Shivani Tiwary & Rosa Rakownikow Jersie-Christensen & Cristina Chiva & Marc R. Dickinson & Martin Kuhlwilm & Marc Manuel & , 2020.
"The dental proteome of Homo antecessor,"
Nature, Nature, vol. 580(7802), pages 235-238, April.
Handle:
RePEc:nat:nature:v:580:y:2020:i:7802:d:10.1038_s41586-020-2153-8
DOI: 10.1038/s41586-020-2153-8
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Cited by:
- Fabrice Demeter & Clément Zanolli & Kira E. Westaway & Renaud Joannes-Boyau & Philippe Duringer & Mike W. Morley & Frido Welker & Patrick L. Rüther & Matthew M. Skinner & Hugh McColl & Charleen Gaunit, 2022.
"A Middle Pleistocene Denisovan molar from the Annamite Chain of northern Laos,"
Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Patrick Leopold Rüther & Immanuel Mirnes Husic & Pernille Bangsgaard & Kristian Murphy Gregersen & Pernille Pantmann & Milena Carvalho & Ricardo Miguel Godinho & Lukas Friedl & João Cascalheira & Albe, 2022.
"SPIN enables high throughput species identification of archaeological bone by proteomics,"
Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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