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Dietary modifications for enhanced cancer therapy

Author

Listed:
  • Naama Kanarek

    (Boston Children’s Hospital
    Harvard Medical School
    Broad Institute of Harvard and Massachusetts Institute of Technology)

  • Boryana Petrova

    (Boston Children’s Hospital)

  • David M. Sabatini

    (Broad Institute of Harvard and Massachusetts Institute of Technology
    Whitehead Institute for Biomedical Research
    Howard Hughes Medical Institute, Massachusetts Institute of Technology
    Koch Institute for Integrative Cancer Research)

Abstract

Tumours depend on nutrients supplied by the host for their growth and survival. Modifications to the host’s diet can change nutrient availability in the tumour microenvironment, which might represent a promising strategy for inhibiting tumour growth. Dietary modifications can limit tumour-specific nutritional requirements, alter certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxicity of anti-cancer drugs. Recent reports have suggested that modification of several nutrients in the diet can alter the efficacy of cancer therapies, and some of the newest developments in this quickly expanding field are reviewed here. The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.

Suggested Citation

  • Naama Kanarek & Boryana Petrova & David M. Sabatini, 2020. "Dietary modifications for enhanced cancer therapy," Nature, Nature, vol. 579(7800), pages 507-517, March.
    • Handle: RePEc:nat:nature:v:579:y:2020:i:7800:d:10.1038_s41586-020-2124-0
    DOI: 10.1038/s41586-020-2124-0
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    Cited by:

    1. Daniele Nucci & Vincenza Gianfredi & Pietro Ferrara & Omar Enzo Santangelo & Beatrice Varotto & Alessandra Feltrin & Antonella Galiano & Mariateresa Nardi, 2023. "Association between Malnutrition and Depression in Patients with Cancer: The Importance of Nutritional Status Evaluation in Cancer Care," IJERPH, MDPI, vol. 20(3), pages 1-10, January.

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