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Patch repair of deep wounds by mobilized fascia

Author

Listed:
  • Donovan Correa-Gallegos

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Dongsheng Jiang

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Simon Christ

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Pushkar Ramesh

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Haifeng Ye

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Juliane Wannemacher

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Shruthi Kalgudde Gopal

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Qing Yu

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München)

  • Michaela Aichler

    (Helmholtz Zentrum München)

  • Axel Walch

    (Helmholtz Zentrum München)

  • Ursula Mirastschijski

    (Mira-Beau Gender Esthetics
    University of Bremen)

  • Thomas Volz

    (Klinikum rechts der Isar, Technical University of Munich)

  • Yuval Rinkevich

    (Institute of Lung Biology and Disease, Helmholtz Zentrum München
    German Centre for Lung Research (DZL))

Abstract

Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism1–5. Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix. Genetic ablation of fascia fibroblasts prevented matrix from homing into wounds and resulted in defective scars, whereas placing an impermeable film beneath the skin—preventing fascia fibroblasts from migrating upwards—led to chronic open wounds. Thus, fascia contains a specialized prefabricated kit of sentry fibroblasts, embedded within a movable sealant, that preassemble together diverse cell types and matrix components needed to heal wounds. Our findings suggest that chronic and excessive skin wounds may be attributed to the mobility of the fascia matrix.

Suggested Citation

  • Donovan Correa-Gallegos & Dongsheng Jiang & Simon Christ & Pushkar Ramesh & Haifeng Ye & Juliane Wannemacher & Shruthi Kalgudde Gopal & Qing Yu & Michaela Aichler & Axel Walch & Ursula Mirastschijski , 2019. "Patch repair of deep wounds by mobilized fascia," Nature, Nature, vol. 576(7786), pages 287-292, December.
    • Handle: RePEc:nat:nature:v:576:y:2019:i:7786:d:10.1038_s41586-019-1794-y
    DOI: 10.1038/s41586-019-1794-y
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    Cited by:

    1. Shruthi Kalgudde Gopal & Ruoxuan Dai & Ania Maria Stefanska & Meshal Ansari & Jiakuan Zhao & Pushkar Ramesh & Johannes W. Bagnoli & Donovan Correa-Gallegos & Yue Lin & Simon Christ & Ilias Angelidis &, 2023. "Wound infiltrating adipocytes are not myofibroblasts," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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