IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v574y2019i7779d10.1038_s41586-019-1675-4.html
   My bibliography  Save this article

A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila

Author

Listed:
  • Yangkyun Oh

    (New York University School of Medicine)

  • Jason Sih-Yu Lai

    (New York University School of Medicine
    QPS-Qualitix Taiwan)

  • Holly J. Mills

    (New York University School of Medicine
    Ascend Public Charter Schools)

  • Hediye Erdjument-Bromage

    (New York University School of Medicine)

  • Benno Giammarinaro

    (New York University School of Medicine
    School of Optometry, UC Berkeley)

  • Khalil Saadipour

    (New York University School of Medicine)

  • Justin G. Wang

    (New York University School of Medicine
    Salk Institute for Biological Studies)

  • Farhan Abu

    (New York University School of Medicine
    Columbia University)

  • Thomas A. Neubert

    (New York University School of Medicine)

  • Greg S. B. Suh

    (New York University School of Medicine
    Korea Advanced Institute of Science and Technology)

Abstract

Although glucose-sensing neurons were identified more than 50 years ago, the physiological role of glucose sensing in metazoans remains unclear. Here we identify a pair of glucose-sensing neurons with bifurcated axons in the brain of Drosophila. One axon branch projects to insulin-producing cells to trigger the release of Drosophila insulin-like peptide 2 (dilp2) and the other extends to adipokinetic hormone (AKH)–producing cells to inhibit secretion of AKH, the fly analogue of glucagon. These axonal branches undergo synaptic remodelling in response to changes in their internal energy status. Silencing of these glucose-sensing neurons largely disabled the response of insulin-producing cells to glucose and dilp2 secretion, disinhibited AKH secretion in corpora cardiaca and caused hyperglycaemia, a hallmark feature of diabetes mellitus. We propose that these glucose-sensing neurons maintain glucose homeostasis by promoting the secretion of dilp2 and suppressing the release of AKH when haemolymph glucose levels are high.

Suggested Citation

  • Yangkyun Oh & Jason Sih-Yu Lai & Holly J. Mills & Hediye Erdjument-Bromage & Benno Giammarinaro & Khalil Saadipour & Justin G. Wang & Farhan Abu & Thomas A. Neubert & Greg S. B. Suh, 2019. "A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila," Nature, Nature, vol. 574(7779), pages 559-564, October.
    • Handle: RePEc:nat:nature:v:574:y:2019:i:7779:d:10.1038_s41586-019-1675-4
    DOI: 10.1038/s41586-019-1675-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-019-1675-4
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-019-1675-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alka Singh & Kandahalli Venkataranganayaka Abhilasha & Kathya R. Acharya & Haibo Liu & Niraj K. Nirala & Velayoudame Parthibane & Govind Kunduri & Thiruvaimozhi Abimannan & Jacob Tantalla & Lihua Juli, 2024. "A nutrient responsive lipase mediates gut-brain communication to regulate insulin secretion in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Mami Nakamizo-Dojo & Kenichi Ishii & Jiro Yoshino & Masato Tsuji & Kazuo Emoto, 2023. "Descending GABAergic pathway links brain sugar-sensing to peripheral nociceptive gating in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:574:y:2019:i:7779:d:10.1038_s41586-019-1675-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.