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Sleep modulates haematopoiesis and protects against atherosclerosis

Author

Listed:
  • Cameron S. McAlpine

    (Massachusetts General Hospital and Harvard Medical School)

  • Máté G. Kiss

    (Massachusetts General Hospital and Harvard Medical School
    Medical University of Vienna
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences)

  • Sara Rattik

    (Massachusetts General Hospital and Harvard Medical School)

  • Shun He

    (Massachusetts General Hospital and Harvard Medical School)

  • Anne Vassalli

    (University of Lausanne)

  • Colin Valet

    (Massachusetts General Hospital and Harvard Medical School)

  • Atsushi Anzai

    (Massachusetts General Hospital and Harvard Medical School)

  • Christopher T. Chan

    (Massachusetts General Hospital and Harvard Medical School)

  • John E. Mindur

    (Massachusetts General Hospital and Harvard Medical School)

  • Florian Kahles

    (Massachusetts General Hospital and Harvard Medical School)

  • Wolfram C. Poller

    (Massachusetts General Hospital and Harvard Medical School)

  • Vanessa Frodermann

    (Massachusetts General Hospital and Harvard Medical School)

  • Ashley M. Fenn

    (Massachusetts General Hospital and Harvard Medical School)

  • Annemijn F. Gregory

    (Massachusetts General Hospital and Harvard Medical School)

  • Lennard Halle

    (Massachusetts General Hospital and Harvard Medical School)

  • Yoshiko Iwamoto

    (Massachusetts General Hospital and Harvard Medical School)

  • Friedrich F. Hoyer

    (Massachusetts General Hospital and Harvard Medical School)

  • Christoph J. Binder

    (Medical University of Vienna
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences)

  • Peter Libby

    (Brigham and Women’s Hospital)

  • Mehdi Tafti

    (University of Lausanne)

  • Thomas E. Scammell

    (Beth Israel Deaconess Medical Center)

  • Matthias Nahrendorf

    (Massachusetts General Hospital and Harvard Medical School
    Massachusetts General Hospital and Harvard Medical School)

  • Filip K. Swirski

    (Massachusetts General Hospital and Harvard Medical School
    Massachusetts General Hospital and Harvard Medical School)

Abstract

Sleep is integral to life1. Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease2, we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice. We show that mice subjected to sleep fragmentation produce more Ly-6Chigh monocytes, develop larger atherosclerotic lesions and produce less hypocretin—a stimulatory and wake-promoting neuropeptide—in the lateral hypothalamus. Hypocretin controls myelopoiesis by restricting the production of CSF1 by hypocretin-receptor-expressing pre-neutrophils in the bone marrow. Whereas hypocretin-null and haematopoietic hypocretin-receptor-null mice develop monocytosis and accelerated atherosclerosis, sleep-fragmented mice with either haematopoietic CSF1 deficiency or hypocretin supplementation have reduced numbers of circulating monocytes and smaller atherosclerotic lesions. Together, these results identify a neuro-immune axis that links sleep to haematopoiesis and atherosclerosis.

Suggested Citation

  • Cameron S. McAlpine & Máté G. Kiss & Sara Rattik & Shun He & Anne Vassalli & Colin Valet & Atsushi Anzai & Christopher T. Chan & John E. Mindur & Florian Kahles & Wolfram C. Poller & Vanessa Froderman, 2019. "Sleep modulates haematopoiesis and protects against atherosclerosis," Nature, Nature, vol. 566(7744), pages 383-387, February.
    • Handle: RePEc:nat:nature:v:566:y:2019:i:7744:d:10.1038_s41586-019-0948-2
    DOI: 10.1038/s41586-019-0948-2
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    Cited by:

    1. Na Chen & Lizhe Guo & Lu Wang & Sisi Dai & Xiaocheng Zhu & E. Wang, 2024. "Sleep fragmentation exacerbates myocardial ischemia‒reperfusion injury by promoting copper overload in cardiomyocytes," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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