Author
Listed:
- Takeshi Tanoue
(Keio University School of Medicine
JSR-Keio University Medical and Chemical Innovation Center
RIKEN Center for Integrative Medical Sciences)
- Satoru Morita
(Keio University School of Medicine)
- Damian R. Plichta
(Broad Institute of MIT and Harvard)
- Ashwin N. Skelly
(Keio University School of Medicine)
- Wataru Suda
(RIKEN Center for Integrative Medical Sciences
Waseda University
The University of Tokyo)
- Yuki Sugiura
(Keio University School of Medicine)
- Seiko Narushima
(Keio University School of Medicine
RIKEN Center for Integrative Medical Sciences)
- Hera Vlamakis
(Broad Institute of MIT and Harvard)
- Iori Motoo
(RIKEN Center for Integrative Medical Sciences)
- Kayoko Sugita
(Keio University School of Medicine)
- Atsushi Shiota
(Keio University School of Medicine
JSR-Keio University Medical and Chemical Innovation Center)
- Kozue Takeshita
(Keio University School of Medicine)
- Keiko Yasuma-Mitobe
(Keio University School of Medicine)
- Dieter Riethmacher
(Nazarbayev University School of Medicine)
- Tsuneyasu Kaisho
(Wakayama Medical University)
- Jason M. Norman
(Vedanta Biosciences)
- Daniel Mucida
(The Rockefeller University)
- Makoto Suematsu
(Keio University School of Medicine)
- Tomonori Yaguchi
(Keio University School of Medicine)
- Vanni Bucci
(University of Massachusetts Dartmouth)
- Takashi Inoue
(Central Institute for Experimental Animals)
- Yutaka Kawakami
(Keio University School of Medicine)
- Bernat Olle
(Vedanta Biosciences)
- Bruce Roberts
(Vedanta Biosciences)
- Masahira Hattori
(RIKEN Center for Integrative Medical Sciences
Waseda University
The University of Tokyo)
- Ramnik J. Xavier
(Broad Institute of MIT and Harvard
Massachusetts General Hospital and Harvard Medical School)
- Koji Atarashi
(Keio University School of Medicine
JSR-Keio University Medical and Chemical Innovation Center
RIKEN Center for Integrative Medical Sciences)
- Kenya Honda
(Keio University School of Medicine
JSR-Keio University Medical and Chemical Innovation Center
RIKEN Center for Integrative Medical Sciences)
Abstract
There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103+ dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.
Suggested Citation
Takeshi Tanoue & Satoru Morita & Damian R. Plichta & Ashwin N. Skelly & Wataru Suda & Yuki Sugiura & Seiko Narushima & Hera Vlamakis & Iori Motoo & Kayoko Sugita & Atsushi Shiota & Kozue Takeshita & K, 2019.
"A defined commensal consortium elicits CD8 T cells and anti-cancer immunity,"
Nature, Nature, vol. 565(7741), pages 600-605, January.
Handle:
RePEc:nat:nature:v:565:y:2019:i:7741:d:10.1038_s41586-019-0878-z
DOI: 10.1038/s41586-019-0878-z
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:565:y:2019:i:7741:d:10.1038_s41586-019-0878-z. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.