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A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Author

Listed:
  • Takeshi Tanoue

    (Keio University School of Medicine
    JSR-Keio University Medical and Chemical Innovation Center
    RIKEN Center for Integrative Medical Sciences)

  • Satoru Morita

    (Keio University School of Medicine)

  • Damian R. Plichta

    (Broad Institute of MIT and Harvard)

  • Ashwin N. Skelly

    (Keio University School of Medicine)

  • Wataru Suda

    (RIKEN Center for Integrative Medical Sciences
    Waseda University
    The University of Tokyo)

  • Yuki Sugiura

    (Keio University School of Medicine)

  • Seiko Narushima

    (Keio University School of Medicine
    RIKEN Center for Integrative Medical Sciences)

  • Hera Vlamakis

    (Broad Institute of MIT and Harvard)

  • Iori Motoo

    (RIKEN Center for Integrative Medical Sciences)

  • Kayoko Sugita

    (Keio University School of Medicine)

  • Atsushi Shiota

    (Keio University School of Medicine
    JSR-Keio University Medical and Chemical Innovation Center)

  • Kozue Takeshita

    (Keio University School of Medicine)

  • Keiko Yasuma-Mitobe

    (Keio University School of Medicine)

  • Dieter Riethmacher

    (Nazarbayev University School of Medicine)

  • Tsuneyasu Kaisho

    (Wakayama Medical University)

  • Jason M. Norman

    (Vedanta Biosciences)

  • Daniel Mucida

    (The Rockefeller University)

  • Makoto Suematsu

    (Keio University School of Medicine)

  • Tomonori Yaguchi

    (Keio University School of Medicine)

  • Vanni Bucci

    (University of Massachusetts Dartmouth)

  • Takashi Inoue

    (Central Institute for Experimental Animals)

  • Yutaka Kawakami

    (Keio University School of Medicine)

  • Bernat Olle

    (Vedanta Biosciences)

  • Bruce Roberts

    (Vedanta Biosciences)

  • Masahira Hattori

    (RIKEN Center for Integrative Medical Sciences
    Waseda University
    The University of Tokyo)

  • Ramnik J. Xavier

    (Broad Institute of MIT and Harvard
    Massachusetts General Hospital and Harvard Medical School)

  • Koji Atarashi

    (Keio University School of Medicine
    JSR-Keio University Medical and Chemical Innovation Center
    RIKEN Center for Integrative Medical Sciences)

  • Kenya Honda

    (Keio University School of Medicine
    JSR-Keio University Medical and Chemical Innovation Center
    RIKEN Center for Integrative Medical Sciences)

Abstract

There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103+ dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.

Suggested Citation

  • Takeshi Tanoue & Satoru Morita & Damian R. Plichta & Ashwin N. Skelly & Wataru Suda & Yuki Sugiura & Seiko Narushima & Hera Vlamakis & Iori Motoo & Kayoko Sugita & Atsushi Shiota & Kozue Takeshita & K, 2019. "A defined commensal consortium elicits CD8 T cells and anti-cancer immunity," Nature, Nature, vol. 565(7741), pages 600-605, January.
  • Handle: RePEc:nat:nature:v:565:y:2019:i:7741:d:10.1038_s41586-019-0878-z
    DOI: 10.1038/s41586-019-0878-z
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    Cited by:

    1. Huiyuan Zhu & Man Li & Dexi Bi & Huiqiong Yang & Yaohui Gao & Feifei Song & Jiayi Zheng & Ruting Xie & Youhua Zhang & Hu Liu & Xuebing Yan & Cheng Kong & Yefei Zhu & Qian Xu & Qing Wei & Huanlong Qin, 2024. "Fusobacterium nucleatum promotes tumor progression in KRAS p.G12D-mutant colorectal cancer by binding to DHX15," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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