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Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour

Author

Listed:
  • Joshua H. Jennings

    (Stanford University)

  • Christina K. Kim

    (Stanford University)

  • James H. Marshel

    (Stanford University)

  • Misha Raffiee

    (Stanford University)

  • Li Ye

    (Stanford University
    Howard Hughes Medical Institute)

  • Sean Quirin

    (Stanford University)

  • Sally Pak

    (Stanford University)

  • Charu Ramakrishnan

    (Stanford University)

  • Karl Deisseroth

    (Stanford University
    Stanford University
    Stanford University
    Howard Hughes Medical Institute)

Abstract

Categorically distinct basic drives (for example, for social versus feeding behaviour1–3) can exert potent influences on each other; such interactions are likely to have important adaptive consequences (such as appropriate regulation of feeding in the context of social hierarchies) and can become maladaptive (such as in clinical settings involving anorexia). It is known that neural systems regulating natural and adaptive caloric intake, and those regulating social behaviours, involve related circuitry4–7, but the causal circuit mechanisms of these drive adjudications are not clear. Here we investigate the causal role in behaviour of cellular-resolution experience-specific neuronal populations in the orbitofrontal cortex, a major reward-processing hub that contains diverse activity-specific neuronal populations that respond differentially to various aspects of caloric intake8–13 and social stimuli14,15. We coupled genetically encoded activity imaging with the development and application of methods for optogenetic control of multiple individually defined cells, to both optically monitor and manipulate the activity of many orbitofrontal cortex neurons at the single-cell level in real time during rewarding experiences (caloric consumption and social interaction). We identified distinct populations within the orbitofrontal cortex that selectively responded to either caloric rewards or social stimuli, and found that activity of individually specified naturally feeding-responsive neurons was causally linked to increased feeding behaviour; this effect was selective as, by contrast, single-cell resolution activation of naturally social-responsive neurons inhibited feeding, and activation of neurons responsive to neither feeding nor social stimuli did not alter feeding behaviour. These results reveal the presence of potent cellular-level subnetworks within the orbitofrontal cortex that can be precisely engaged to bidirectionally control feeding behaviours subject to, for example, social influences.

Suggested Citation

  • Joshua H. Jennings & Christina K. Kim & James H. Marshel & Misha Raffiee & Li Ye & Sean Quirin & Sally Pak & Charu Ramakrishnan & Karl Deisseroth, 2019. "Interacting neural ensembles in orbitofrontal cortex for social and feeding behaviour," Nature, Nature, vol. 565(7741), pages 645-649, January.
  • Handle: RePEc:nat:nature:v:565:y:2019:i:7741:d:10.1038_s41586-018-0866-8
    DOI: 10.1038/s41586-018-0866-8
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    Cited by:

    1. Jennifer Isaac & Sonia Corbett Karkare & Hymavathy Balasubramanian & Nicholas Schappaugh & Jarildy Larimar Javier & Maha Rashid & Malavika Murugan, 2024. "Sex differences in neural representations of social and nonsocial reward in the medial prefrontal cortex," Nature Communications, Nature, vol. 15(1), pages 1-27, December.

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