IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v565y2019i7738d10.1038_s41586-018-0801-z.html
   My bibliography  Save this article

Thermal stress induces glycolytic beige fat formation via a myogenic state

Author

Listed:
  • Yong Chen

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California
    Huazhong University of Science and Technology)

  • Kenji Ikeda

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Takeshi Yoneshiro

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Annarita Scaramozza

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Kazuki Tajima

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Qiang Wang

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Kyeongkyu Kim

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Kosaku Shinoda

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California
    Albert Einstein College of Medicine)

  • Carlos Henrique Sponton

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Zachary Brown

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Andrew Brack

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

  • Shingo Kajimura

    (UCSF Diabetes Center
    Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
    University of California)

Abstract

Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue. However, the molecular mechanisms by which physiological or pathological cues evoke developmental plasticity remain incompletely understood. Here we report a type of beige adipocyte that has a critical role in chronic cold adaptation in the absence of β-adrenergic receptor signalling. This beige fat is distinct from conventional beige fat with respect to developmental origin and regulation, and displays enhanced glucose oxidation. We therefore refer to it as glycolytic beige fat. Mechanistically, we identify GA-binding protein α as a regulator of glycolytic beige adipocyte differentiation through a myogenic intermediate. Our study reveals a non-canonical adaptive mechanism by which thermal stress induces progenitor cell plasticity and recruits a distinct form of thermogenic cell that is required for energy homeostasis and survival.

Suggested Citation

  • Yong Chen & Kenji Ikeda & Takeshi Yoneshiro & Annarita Scaramozza & Kazuki Tajima & Qiang Wang & Kyeongkyu Kim & Kosaku Shinoda & Carlos Henrique Sponton & Zachary Brown & Andrew Brack & Shingo Kajimu, 2019. "Thermal stress induces glycolytic beige fat formation via a myogenic state," Nature, Nature, vol. 565(7738), pages 180-185, January.
  • Handle: RePEc:nat:nature:v:565:y:2019:i:7738:d:10.1038_s41586-018-0801-z
    DOI: 10.1038/s41586-018-0801-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-018-0801-z
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-018-0801-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Qingbo Chen & Lei Huang & Dongning Pan & Kai Hu & Rui Li & Randall H. Friedline & Jason K. Kim & Lihua Julie Zhu & David A. Guertin & Yong-Xu Wang, 2022. "A brown fat-enriched adipokine Adissp controls adipose thermogenesis and glucose homeostasis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Lai Yee Cheong & Baile Wang & Qin Wang & Leigang Jin & Kelvin H. M. Kwok & Xiaoping Wu & Lingling Shu & Huige Lin & Sookja Kim Chung & Kenneth K. Y. Cheng & Ruby L. C. Hoo & Aimin Xu, 2023. "Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Yong Geun Jeon & Hahn Nahmgoong & Jiyoung Oh & Dabin Lee & Dong Wook Kim & Jane Eunsoo Kim & Ye Young Kim & Yul Ji & Ji Seul Han & Sung Min Kim & Jee Hyung Sohn & Won Taek Lee & Sun Won Kim & Jeu Park, 2024. "Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Abigail M. Benvie & Derek Lee & Benjamin M. Steiner & Siwen Xue & Yuwei Jiang & Daniel C. Berry, 2023. "Age-dependent Pdgfrβ signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:565:y:2019:i:7738:d:10.1038_s41586-018-0801-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.