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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression

Author

Listed:
  • Felix Leroy

    (Columbia University)

  • Jung Park

    (Columbia University)

  • Arun Asok

    (Columbia University)

  • David H. Brann

    (Columbia University)

  • Torcato Meira

    (Columbia University
    University of Minho
    ICVS/3B’s, PT Government Associate Laboratory)

  • Lara M. Boyle

    (Columbia University)

  • Eric W. Buss

    (Columbia University)

  • Eric R. Kandel

    (Columbia University
    Columbia University)

  • Steven A. Siegelbaum

    (Columbia University)

Abstract

Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced immediately before an attack. Activation of the lateral septum by CA2 recruits a circuit that disinhibits a subnucleus of the ventromedial hypothalamus that is known to trigger attack. The social hormone arginine vasopressin enhances social aggression by acting on arginine vasopressin 1b receptors on CA2 presynaptic terminals in the lateral septum to facilitate excitatory synaptic transmission. In this manner, release of arginine vasopressin in the lateral septum, driven by an animal’s internal state, may serve as a modulatory control that determines whether CA2 activity leads to declarative memory of a social encounter and/or promotes motivated social aggression.

Suggested Citation

  • Felix Leroy & Jung Park & Arun Asok & David H. Brann & Torcato Meira & Lara M. Boyle & Eric W. Buss & Eric R. Kandel & Steven A. Siegelbaum, 2018. "A circuit from hippocampal CA2 to lateral septum disinhibits social aggression," Nature, Nature, vol. 564(7735), pages 213-218, December.
  • Handle: RePEc:nat:nature:v:564:y:2018:i:7735:d:10.1038_s41586-018-0772-0
    DOI: 10.1038/s41586-018-0772-0
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    Cited by:

    1. Darshini Mahadevia & Rinki Saha & Alessia Manganaro & Nao Chuhma & Annette Ziolkowski-Blake & Ashlea A. Morgan & Dani Dumitriu & Stephen Rayport & Mark S. Ansorge, 2021. "Dopamine promotes aggression in mice via ventral tegmental area to lateral septum projections," Nature Communications, Nature, vol. 12(1), pages 1-12, December.

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