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Improved reference genome of Aedes aegypti informs arbovirus vector control

Author

Listed:
  • Benjamin J. Matthews

    (The Rockefeller University
    Howard Hughes Medical Institute
    Kavli Neural Systems Institute)

  • Olga Dudchenko

    (Baylor College of Medicine
    Baylor College of Medicine
    Rice University
    Rice University)

  • Sarah B. Kingan

    (Pacific Biosciences)

  • Sergey Koren

    (National Human Genome Research Institute, National Institutes of Health)

  • Igor Antoshechkin

    (California Institute of Technology)

  • Jacob E. Crawford

    (Verily Life Sciences)

  • William J. Glassford

    (Columbia University)

  • Margaret Herre

    (The Rockefeller University
    Kavli Neural Systems Institute)

  • Seth N. Redmond

    (Broad Institute of MIT and Harvard
    Harvard T. H. Chan School of Public Health)

  • Noah H. Rose

    (Princeton University
    Princeton University)

  • Gareth D. Weedall

    (Liverpool School of Tropical Medicine
    Liverpool John Moores University)

  • Yang Wu

    (Southern Medical University
    Virginia Tech
    Virginia Tech)

  • Sanjit S. Batra

    (Baylor College of Medicine
    Baylor College of Medicine
    Rice University)

  • Carlos A. Brito-Sierra

    (Purdue University
    Purdue University)

  • Steven D. Buckingham

    (University College London)

  • Corey L. Campbell

    (Colorado State University)

  • Saki Chan

    (Bionano Genomics)

  • Eric Cox

    (National Institutes of Health)

  • Benjamin R. Evans

    (Yale University)

  • Thanyalak Fansiri

    (Armed Forces Research Institute of Medical Sciences (AFRIMS))

  • Igor Filipović

    (QIMR Berghofer Medical Research Institute)

  • Albin Fontaine

    (Institut Pasteur
    Unité de Parasitologie et Entomologie, Département des Maladies Infectieuses, Institut de Recherche Biomédicale des Armées
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 2000
    Aix Marseille Université, IRD, AP-HM, SSA, UMR Vecteurs – Infections Tropicales et Méditerranéennes (VITROME), IHU - Méditerranée Infection)

  • Andrea Gloria-Soria

    (Yale University
    The Connecticut Agricultural Experiment Station)

  • Richard Hall

    (Pacific Biosciences)

  • Vinita S. Joardar

    (National Institutes of Health)

  • Andrew K. Jones

    (Oxford Brookes University)

  • Raissa G. G. Kay

    (University of California Riverside)

  • Vamsi K. Kodali

    (National Institutes of Health)

  • Joyce Lee

    (Bionano Genomics)

  • Gareth J. Lycett

    (Liverpool School of Tropical Medicine)

  • Sara N. Mitchell

    (Verily Life Sciences)

  • Jill Muehling

    (Pacific Biosciences)

  • Michael R. Murphy

    (National Institutes of Health)

  • Arina D. Omer

    (Baylor College of Medicine
    Baylor College of Medicine
    Rice University)

  • Frederick A. Partridge

    (University College London)

  • Paul Peluso

    (Pacific Biosciences)

  • Aviva Presser Aiden

    (Baylor College of Medicine
    Baylor College of Medicine
    Rice University
    Texas Children’s Hospital)

  • Vidya Ramasamy

    (Oxford Brookes University)

  • Gordana Rašić

    (QIMR Berghofer Medical Research Institute)

  • Sourav Roy

    (University of California)

  • Karla Saavedra-Rodriguez

    (Colorado State University)

  • Shruti Sharan

    (Purdue University
    Purdue University)

  • Atashi Sharma

    (Virginia Tech
    Virginia Tech)

  • Melissa Laird Smith

    (Pacific Biosciences)

  • Joe Turner

    (University of Liverpool)

  • Allison M. Weakley

    (Verily Life Sciences)

  • Zhilei Zhao

    (Princeton University
    Princeton University)

  • Omar S. Akbari

    (University of California, San Diego
    University of California, San Diego)

  • William C. Black

    (Colorado State University)

  • Han Cao

    (Bionano Genomics)

  • Alistair C. Darby

    (University of Liverpool)

  • Catherine A. Hill

    (Purdue University
    Purdue University)

  • J. Spencer Johnston

    (Texas A&M University)

  • Terence D. Murphy

    (National Institutes of Health)

  • Alexander S. Raikhel

    (University of California)

  • David B. Sattelle

    (University College London)

  • Igor V. Sharakhov

    (Virginia Tech
    Virginia Tech
    Tomsk State University)

  • Bradley J. White

    (Verily Life Sciences)

  • Li Zhao

    (The Rockefeller University)

  • Erez Lieberman Aiden

    (Baylor College of Medicine
    Baylor College of Medicine
    Rice University
    Rice University)

  • Richard S. Mann

    (Columbia University)

  • Louis Lambrechts

    (Institut Pasteur
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 2000)

  • Jeffrey R. Powell

    (Yale University)

  • Maria V. Sharakhova

    (Virginia Tech
    Virginia Tech
    Tomsk State University)

  • Zhijian Tu

    (Virginia Tech
    Virginia Tech)

  • Hugh M. Robertson

    (University of Illinois at Urbana-Champaign)

  • Carolyn S. McBride

    (Princeton University
    Princeton University)

  • Alex R. Hastie

    (Bionano Genomics)

  • Jonas Korlach

    (Pacific Biosciences)

  • Daniel E. Neafsey

    (Broad Institute of MIT and Harvard
    Harvard T. H. Chan School of Public Health)

  • Adam M. Phillippy

    (National Human Genome Research Institute, National Institutes of Health)

  • Leslie B. Vosshall

    (The Rockefeller University
    Howard Hughes Medical Institute
    Kavli Neural Systems Institute)

Abstract

Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.

Suggested Citation

  • Benjamin J. Matthews & Olga Dudchenko & Sarah B. Kingan & Sergey Koren & Igor Antoshechkin & Jacob E. Crawford & William J. Glassford & Margaret Herre & Seth N. Redmond & Noah H. Rose & Gareth D. Weed, 2018. "Improved reference genome of Aedes aegypti informs arbovirus vector control," Nature, Nature, vol. 563(7732), pages 501-507, November.
    • Handle: RePEc:nat:nature:v:563:y:2018:i:7732:d:10.1038_s41586-018-0692-z
    DOI: 10.1038/s41586-018-0692-z
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    Citations

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    Cited by:

    1. Thomas L. Schmidt & Nancy M. Endersby-Harshman & Anthony R. J. Rooyen & Michelle Katusele & Rebecca Vinit & Leanne J. Robinson & Moses Laman & Stephan Karl & Ary A. Hoffmann, 2024. "Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Vinícius G. Contessoto & Olga Dudchenko & Erez Lieberman Aiden & Peter G. Wolynes & José N. Onuchic & Michele Pierro, 2023. "Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Sebald A. N. Verkuijl & Estela Gonzalez & Ming Li & Joshua X. D. Ang & Nikolay P. Kandul & Michelle A. E. Anderson & Omar S. Akbari & Michael B. Bonsall & Luke Alphey, 2022. "A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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