IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v562y2018i7726d10.1038_s41586-018-0552-x.html
   My bibliography  Save this article

Erythro-myeloid progenitors contribute endothelial cells to blood vessels

Author

Listed:
  • Alice Plein

    (University College London)

  • Alessandro Fantin

    (University College London)

  • Laura Denti

    (University College London)

  • Jeffrey W. Pollard

    (University of Edinburgh)

  • Christiana Ruhrberg

    (University College London)

Abstract

The earliest blood vessels in mammalian embryos are formed when endothelial cells differentiate from angioblasts and coalesce into tubular networks. Thereafter, the endothelium is thought to expand solely by proliferation of pre-existing endothelial cells. Here we show that a complementary source of endothelial cells is recruited into pre-existing vasculature after differentiation from the earliest precursors of erythrocytes, megakaryocytes and macrophages, the erythro-myeloid progenitors (EMPs) that are born in the yolk sac. A first wave of EMPs contributes endothelial cells to the yolk sac endothelium, and a second wave of EMPs colonizes the embryo and contributes endothelial cells to intraembryonic endothelium in multiple organs, where they persist into adulthood. By demonstrating that EMPs constitute a hitherto unrecognized source of endothelial cells, we reveal that embryonic blood vascular endothelium expands in a dual mechanism that involves both the proliferation of pre-existing endothelial cells and the incorporation of endothelial cells derived from haematopoietic precursors.

Suggested Citation

  • Alice Plein & Alessandro Fantin & Laura Denti & Jeffrey W. Pollard & Christiana Ruhrberg, 2018. "Erythro-myeloid progenitors contribute endothelial cells to blood vessels," Nature, Nature, vol. 562(7726), pages 223-228, October.
    • Handle: RePEc:nat:nature:v:562:y:2018:i:7726:d:10.1038_s41586-018-0552-x
    DOI: 10.1038/s41586-018-0552-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-018-0552-x
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/s41586-018-0552-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Anna E. Williamson & Sanuri Liyanage & Mohammadhossein Hassanshahi & Malathi S. I. Dona & Deborah Toledo-Flores & Dang X. A. Tran & Catherine Dimasi & Nisha Schwarz & Sanuja Fernando & Thalia Salagara, 2024. "Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:562:y:2018:i:7726:d:10.1038_s41586-018-0552-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.