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In vivo reprogramming of wound-resident cells generates skin epithelial tissue

Author

Listed:
  • Masakazu Kurita

    (The Salk Institute for Biological Studies
    Kyorin University School of Medicine)

  • Toshikazu Araoka

    (The Salk Institute for Biological Studies
    Campus de los Jerónimos)

  • Tomoaki Hishida

    (The Salk Institute for Biological Studies)

  • David D. O’Keefe

    (The Salk Institute for Biological Studies)

  • Yuta Takahashi

    (The Salk Institute for Biological Studies)

  • Akihisa Sakamoto

    (The Salk Institute for Biological Studies
    Campus de los Jerónimos)

  • Masahiro Sakurai

    (The Salk Institute for Biological Studies
    Campus de los Jerónimos)

  • Keiichiro Suzuki

    (The Salk Institute for Biological Studies)

  • Jun Wu

    (The Salk Institute for Biological Studies)

  • Mako Yamamoto

    (The Salk Institute for Biological Studies)

  • Reyna Hernandez-Benitez

    (The Salk Institute for Biological Studies)

  • Alejandro Ocampo

    (The Salk Institute for Biological Studies)

  • Pradeep Reddy

    (The Salk Institute for Biological Studies)

  • Maxim Nikolaievich Shokhirev

    (The Salk Institute for Biological Studies)

  • Pierre Magistretti

    (King Abdullah University of Science & Technology (KAUST))

  • Estrella Núñez Delicado

    (Campus de los Jerónimos)

  • Hitomi Eto

    (Kyorin University School of Medicine)

  • Kiyonori Harii

    (Kyorin University School of Medicine)

  • Juan Carlos Izpisua Belmonte

    (The Salk Institute for Biological Studies)

Abstract

Large cutaneous ulcers are, in severe cases, life threatening1,2. As the global population ages, non-healing ulcers are becoming increasingly common1,2. Treatment currently requires the transplantation of pre-existing epithelial components, such as skin grafts, or therapy using cultured cells2. Here we develop alternative supplies of epidermal coverage for the treatment of these kinds of wounds. We generated expandable epithelial tissues using in vivo reprogramming of wound-resident mesenchymal cells. Transduction of four transcription factors that specify the skin-cell lineage enabled efficient and rapid de novo epithelialization from the surface of cutaneous ulcers in mice. Our findings may provide a new therapeutic avenue for treating skin wounds and could be extended to other disease situations in which tissue homeostasis and repair are impaired.

Suggested Citation

  • Masakazu Kurita & Toshikazu Araoka & Tomoaki Hishida & David D. O’Keefe & Yuta Takahashi & Akihisa Sakamoto & Masahiro Sakurai & Keiichiro Suzuki & Jun Wu & Mako Yamamoto & Reyna Hernandez-Benitez & A, 2018. "In vivo reprogramming of wound-resident cells generates skin epithelial tissue," Nature, Nature, vol. 561(7722), pages 243-247, September.
    • Handle: RePEc:nat:nature:v:561:y:2018:i:7722:d:10.1038_s41586-018-0477-4
    DOI: 10.1038/s41586-018-0477-4
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    Cited by:

    1. Yang Yang & Chenyu Chu & Li Liu & Chenbing Wang & Chen Hu & Shengan Rung & Yi Man & Yili Qu, 2023. "Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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