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Bioengineering strategies to accelerate stem cell therapeutics

Author

Listed:
  • Christopher M. Madl

    (Stanford University School of Medicine)

  • Sarah C. Heilshorn

    (Stanford University)

  • Helen M. Blau

    (Stanford University School of Medicine)

Abstract

Although only a few stem cell-based therapies are currently available to patients, stem cells hold tremendous regenerative potential, and several exciting clinical applications are on the horizon. Biomaterials with tuneable mechanical and biochemical properties can preserve stem cell function in culture, enhance survival of transplanted cells and guide tissue regeneration. Rapid progress with three-dimensional hydrogel culture platforms provides the opportunity to grow patient-specific organoids, and has led to the discovery of drugs that stimulate endogenous tissue-specific stem cells and enabled screens for drugs to treat disease. Therefore, bioengineering technologies are poised to overcome current bottlenecks and revolutionize the field of regenerative medicine.

Suggested Citation

  • Christopher M. Madl & Sarah C. Heilshorn & Helen M. Blau, 2018. "Bioengineering strategies to accelerate stem cell therapeutics," Nature, Nature, vol. 557(7705), pages 335-342, May.
    • Handle: RePEc:nat:nature:v:557:y:2018:i:7705:d:10.1038_s41586-018-0089-z
    DOI: 10.1038/s41586-018-0089-z
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    Cited by:

    1. Cheng Zhang & Hongyuan Zhu & Xinru Ren & Bin Gao & Bo Cheng & Shaobao Liu & Baoyong Sha & Zhaoqing Li & Zheng Zhang & Yi Lv & Haohua Wang & Hui Guo & Tian Jian Lu & Feng Xu & Guy M. Genin & Min Lin, 2021. "Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Xinwei Liu & Yingying Ye & Liling Zhu & Xiaoyun Xiao & Boxuan Zhou & Yuanting Gu & Hang Si & Huixin Liang & Mingzhu Liu & Jiaqian Li & Qiongchao Jiang & Jiang Li & Shubin Yu & Ruiying Ma & Shicheng Su, 2023. "Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Y. Wang & E. R. Zoneff & J. W. Thomas & N. Hong & L. L. Tan & D. J. McGillivray & A. W. Perriman & K. C. L. Law & L. H. Thompson & N. Moriarty & C. L. Parish & R. J. Williams & C. J. Jackson & D. R. N, 2023. "Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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