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Pancreas regeneration

Author

Listed:
  • Qiao Zhou

    (Harvard University
    Harvard Stem Cell Institute)

  • Douglas A. Melton

    (Harvard University
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute)

Abstract

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone insulin. Human islets possess limited regenerative ability; loss of islet β-cells in diseases such as type 1 diabetes requires therapeutic intervention. The leading strategy for restoration of β-cell mass is through the generation and transplantation of new β-cells derived from human pluripotent stem cells. Other approaches include stimulating endogenous β-cell proliferation, reprogramming non-β-cells to β-like cells, and harvesting islets from genetically engineered animals. Together these approaches form a rich pipeline of therapeutic development for pancreatic regeneration.

Suggested Citation

  • Qiao Zhou & Douglas A. Melton, 2018. "Pancreas regeneration," Nature, Nature, vol. 557(7705), pages 351-358, May.
    • Handle: RePEc:nat:nature:v:557:y:2018:i:7705:d:10.1038_s41586-018-0088-0
    DOI: 10.1038/s41586-018-0088-0
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    Cited by:

    1. Zhuo Ma & Xiaofei Zhang & Wen Zhong & Hongyan Yi & Xiaowei Chen & Yinsuo Zhao & Yanlin Ma & Eli Song & Tao Xu, 2023. "Deciphering early human pancreas development at the single-cell level," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Janne Purhonen & Rishi Banerjee & Vilma Wanne & Nina Sipari & Matthias Mörgelin & Vineta Fellman & Jukka Kallijärvi, 2023. "Mitochondrial complex III deficiency drives c-MYC overexpression and illicit cell cycle entry leading to senescence and segmental progeria," Nature Communications, Nature, vol. 14(1), pages 1-23, December.

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