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Diverse mechanisms for endogenous regeneration and repair in mammalian organs

Author

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  • James M. Wells

    (Cincinnati Children’s Hospital Medical Center)

  • Fiona M. Watt

    (Guy’s Hospital Campus, King’s College London)

Abstract

Mammalian organs comprise an extraordinary diversity of cell and tissue types. Regenerative organs, such as the skin and gastrointestinal tract, use resident stem cells to maintain tissue function. Organs with a lower cellular turnover, such as the liver and lungs, mostly rely on proliferation of committed progenitor cells. In many organs, injury reveals the plasticity of both resident stem cells and differentiated cells. The ability of resident cells to maintain and repair organs diminishes with age, whereas, paradoxically, the risk of cancer increases. New therapeutic approaches aim to harness cell plasticity for tissue repair and regeneration while avoiding the risk of malignant transformation of cells.

Suggested Citation

  • James M. Wells & Fiona M. Watt, 2018. "Diverse mechanisms for endogenous regeneration and repair in mammalian organs," Nature, Nature, vol. 557(7705), pages 322-328, May.
    • Handle: RePEc:nat:nature:v:557:y:2018:i:7705:d:10.1038_s41586-018-0073-7
    DOI: 10.1038/s41586-018-0073-7
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    Cited by:

    1. Hue M. La & Jinyue Liao & Julien M. D. Legrand & Fernando J. Rossello & Ai-Leen Chan & Vijesh Vaghjiani & Jason E. Cain & Antonella Papa & Tin Lap Lee & Robin M. Hobbs, 2022. "Distinctive molecular features of regenerative stem cells in the damaged male germline," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Wei Gu & Xiaofeng Huang & Pratik N. P. Singh & Sanlan Li & Ying Lan & Min Deng & Lauretta A. Lacko & Jesus M. Gomez-Salinero & Shahin Rafii & Michael P. Verzi & Ramesh A. Shivdasani & Qiao Zhou, 2024. "A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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