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A new class of synthetic retinoid antibiotics effective against bacterial persisters

Author

Listed:
  • Wooseong Kim

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Wenpeng Zhu

    (School of Engineering, Brown University)

  • Gabriel Lambert Hendricks

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Daria Van Tyne

    (Harvard Medical School, Massachusetts Eye and Ear Infirmary
    Harvard Medical School)

  • Andrew D. Steele

    (Emory University
    Emory Antibiotic Resistance Center, Emory University)

  • Colleen E. Keohane

    (Emory University
    Emory Antibiotic Resistance Center, Emory University)

  • Nico Fricke

    (School of Engineering, Brown University)

  • Annie L. Conery

    (Massachusetts General Hospital
    Harvard Medical School)

  • Steven Shen

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Wen Pan

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Kiho Lee

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Rajmohan Rajamuthiah

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Beth Burgwyn Fuchs

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

  • Petia M. Vlahovska

    (Northwestern University)

  • William M. Wuest

    (Emory University
    Emory Antibiotic Resistance Center, Emory University)

  • Michael S. Gilmore

    (Harvard Medical School, Massachusetts Eye and Ear Infirmary
    Harvard Medical School)

  • Huajian Gao

    (School of Engineering, Brown University)

  • Frederick M. Ausubel

    (Massachusetts General Hospital
    Harvard Medical School)

  • Eleftherios Mylonakis

    (Rhode Island Hospital, Warren Alpert Medical School of Brown University)

Abstract

Synthetic retinoid compounds can kill both growing and persister MRSA cells by disrupting the membrane lipid bilayer, and are effective in a mouse model of chronic MRSA infection.

Suggested Citation

  • Wooseong Kim & Wenpeng Zhu & Gabriel Lambert Hendricks & Daria Van Tyne & Andrew D. Steele & Colleen E. Keohane & Nico Fricke & Annie L. Conery & Steven Shen & Wen Pan & Kiho Lee & Rajmohan Rajamuthia, 2018. "A new class of synthetic retinoid antibiotics effective against bacterial persisters," Nature, Nature, vol. 556(7699), pages 103-107, April.
    • Handle: RePEc:nat:nature:v:556:y:2018:i:7699:d:10.1038_nature26157
    DOI: 10.1038/nature26157
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    Cited by:

    1. Jiekai Sun & Xu Wang & Ye Gao & Shuangyu Li & Ziwei Hu & Yan Huang & Baoqiang Fan & Xia Wang & Miao Liu & Chunhua Qiao & Wei Zhang & Yipeng Wang & Xingyue Ji, 2024. "H2S scavenger as a broad-spectrum strategy to deplete bacteria-derived H2S for antibacterial sensitization," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Tsuyoshi Mikkaichi & Michael R Yeaman & Alexander Hoffmann & MRSA Systems Immunobiology Group, 2019. "Identifying determinants of persistent MRSA bacteremia using mathematical modeling," PLOS Computational Biology, Public Library of Science, vol. 15(7), pages 1-26, July.
    3. Bingyan Wei & Tao Zhang & Pengyu Wang & Yihui Pan & Jiahui Li & Weizhong Chen & Min Zhang & Quanjiang Ji & Wenjuan Wu & Lefu Lan & Jianhua Gan & Cai-Guang Yang, 2022. "Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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