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Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

Author

Listed:
  • Giovanna Scapin

    (Merck & Co.)

  • Venkata P. Dandey

    (Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center)

  • Zhening Zhang

    (Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center)

  • Winifred Prosise

    (Merck & Co.)

  • Alan Hruza

    (Merck & Co.)

  • Theresa Kelly

    (Merck & Co., NMR & Protein Products Characterization)

  • Todd Mayhood

    (Merck & Co., NMR & Protein Products Characterization)

  • Corey Strickland

    (Merck & Co.)

  • Clinton S. Potter

    (Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center)

  • Bridget Carragher

    (Simons Electron Microscopy Center, National Resource for Automated Molecular Microscopy, New York Structural Biology Center)

Abstract

Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.

Suggested Citation

  • Giovanna Scapin & Venkata P. Dandey & Zhening Zhang & Winifred Prosise & Alan Hruza & Theresa Kelly & Todd Mayhood & Corey Strickland & Clinton S. Potter & Bridget Carragher, 2018. "Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis," Nature, Nature, vol. 556(7699), pages 122-125, April.
    • Handle: RePEc:nat:nature:v:556:y:2018:i:7699:d:10.1038_nature26153
    DOI: 10.1038/nature26153
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    Cited by:

    1. Kohdai Yamada & Ryouhei Shioya & Kohei Nishino & Hirotake Furihata & Atsushi Hijikata & Mika K. Kaneko & Yukinari Kato & Tsuyoshi Shirai & Hidetaka Kosako & Tatsuya Sawasaki, 2023. "Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Junhee Park & Jie Li & John P. Mayer & Kerri A. Ball & Jiayi Wu & Catherine Hall & Domenico Accili & Michael H. B. Stowell & Xiao-chen Bai & Eunhee Choi, 2022. "Activation of the insulin receptor by an insulin mimetic peptide," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Margaret Wu & Ester Carballo-Jane & Haihong Zhou & Peter Zafian & Ge Dai & Mindy Liu & Julie Lao & Terri Kelly & Dan Shao & Judith Gorski & Dmitri Pissarnitski & Ahmet Kekec & Ying Chen & Stephen F. P, 2022. "Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Nicholas S. Kirk & Qi Chen & Yingzhe Ginger Wu & Anastasia L. Asante & Haitao Hu & Juan F. Espinosa & Francisco Martínez-Olid & Mai B. Margetts & Faiz A. Mohammed & Vladislav V. Kiselyov & David G. Ba, 2022. "Activation of the human insulin receptor by non-insulin-related peptides," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Junhong Kim & Na-Oh Yunn & Mangeun Park & Jihan Kim & Seongeun Park & Yoojoong Kim & Jeongeun Noh & Sung Ho Ryu & Yunje Cho, 2022. "Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    6. Hirofumi Nagao & Ashok Kumar Jayavelu & Weikang Cai & Hui Pan & Jonathan M. Dreyfuss & Thiago M. Batista & Bruna B. Brandão & Matthias Mann & C. Ronald Kahn, 2023. "Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Robert A. Saxton & Nathanael A. Caveney & Maria Dolores Moya-Garzon & Karsten D. Householder & Grayson E. Rodriguez & Kylie A. Burdsall & Jonathan Z. Long & K. Christopher Garcia, 2023. "Structural insights into the mechanism of leptin receptor activation," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    8. Cristina M. Viola & Orsolya Frittmann & Huw T. Jenkins & Talha Shafi & Pierre Meyts & Andrzej M. Brzozowski, 2023. "Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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