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Molecular nucleation mechanisms and control strategies for crystal polymorph selection

Author

Listed:
  • Alexander E. S. Van Driessche

    (Université Grenoble Alpes, Université Savoie Mont Blanc, CNRS, IRD, IFSTTAR, ISTerre)

  • Nani Van Gerven

    (Structural Biology Brussels, Vrije Universiteit Brussel
    Structural and Molecular Microbiology, Structural Biology Research Center)

  • Paul H. H. Bomans

    (Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
    Institute for Complex Molecular Systems, Eindhoven University of Technology)

  • Rick R. M. Joosten

    (Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
    Institute for Complex Molecular Systems, Eindhoven University of Technology)

  • Heiner Friedrich

    (Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
    Institute for Complex Molecular Systems, Eindhoven University of Technology)

  • David Gil-Carton

    (Structural Biology Unit, CIC bioGUNE, Parque Tecnológico de Bizkaia)

  • Nico A. J. M. Sommerdijk

    (Laboratory of Materials and Interface Chemistry and Center of Multiscale Electron Microscopy, Eindhoven University of Technology
    Institute for Complex Molecular Systems, Eindhoven University of Technology)

  • Mike Sleutel

    (Structural Biology Brussels, Vrije Universiteit Brussel
    Structural and Molecular Microbiology, Structural Biology Research Center)

Abstract

Cryo-transmission electron microscopy reveals the initiation of glucose isomerase crystals and their growth into different crystalline or gel polymorphs, and shows that mutating specific amino acids controls which polymorph grows.

Suggested Citation

  • Alexander E. S. Van Driessche & Nani Van Gerven & Paul H. H. Bomans & Rick R. M. Joosten & Heiner Friedrich & David Gil-Carton & Nico A. J. M. Sommerdijk & Mike Sleutel, 2018. "Molecular nucleation mechanisms and control strategies for crystal polymorph selection," Nature, Nature, vol. 556(7699), pages 89-94, April.
    • Handle: RePEc:nat:nature:v:556:y:2018:i:7699:d:10.1038_nature25971
    DOI: 10.1038/nature25971
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