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Whole-organism clone tracing using single-cell sequencing

Author

Listed:
  • Anna Alemany

    (Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht)

  • Maria Florescu

    (Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht)

  • Chloé S. Baron

    (Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht)

  • Josi Peterson-Maduro

    (Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht)

  • Alexander van Oudenaarden

    (Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht)

Abstract

A single-cell sequencing method is developed that uses transcriptomics and CRISPR–Cas9 technology to investigate clonal relationships in cells present in different zebrafish tissues.

Suggested Citation

  • Anna Alemany & Maria Florescu & Chloé S. Baron & Josi Peterson-Maduro & Alexander van Oudenaarden, 2018. "Whole-organism clone tracing using single-cell sequencing," Nature, Nature, vol. 556(7699), pages 108-112, April.
    • Handle: RePEc:nat:nature:v:556:y:2018:i:7699:d:10.1038_nature25969
    DOI: 10.1038/nature25969
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    Citations

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    Cited by:

    1. Xinhai Pan & Hechen Li & Pranav Putta & Xiuwei Zhang, 2023. "LinRace: cell division history reconstruction of single cells using paired lineage barcode and gene expression data," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Yelyzaveta Shlyakhtina & Bianca Bloechl & Maximiliano M. Portal, 2023. "BdLT-Seq as a barcode decay-based method to unravel lineage-linked transcriptome plasticity," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Zhu, Guang & Lin, Zhenhua, 2021. "Commentary on statistical mechanical models of cancer," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 572(C).
    4. Damien G Hicks & Terence P Speed & Mohammed Yassin & Sarah M Russell, 2019. "Maps of variability in cell lineage trees," PLOS Computational Biology, Public Library of Science, vol. 15(2), pages 1-32, February.
    5. A. S. Eisele & M. Tarbier & A. A. Dormann & V. Pelechano & D. M. Suter, 2024. "Gene-expression memory-based prediction of cell lineages from scRNA-seq datasets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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