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Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

Author

Listed:
  • Devram S. Ghorpade

    (Columbia University Medical Center)

  • Lale Ozcan

    (Columbia University Medical Center)

  • Ze Zheng

    (Columbia University Medical Center)

  • Sarah M. Nicoloro

    (Program in Molecular Medicine, University of Massachusetts Medical School)

  • Yuefei Shen

    (Program in Molecular Medicine, University of Massachusetts Medical School)

  • Emily Chen

    (Proteomics Shared Resource in the Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center
    Herbert Irving Comprehensive Cancer Center Proteomics Shared Resource, Columbia University Medical Center)

  • Matthias Blüher

    (University of Leipzig)

  • Michael P. Czech

    (Program in Molecular Medicine, University of Massachusetts Medical School)

  • Ira Tabas

    (Columbia University Medical Center
    Columbia University Medical Center)

Abstract

Hepatocytes secrete DPP4, which promotes adipose tissue inflammation and insulin resistance in obese mice, suggesting a new specific target for treatment of metabolic disorders.

Suggested Citation

  • Devram S. Ghorpade & Lale Ozcan & Ze Zheng & Sarah M. Nicoloro & Yuefei Shen & Emily Chen & Matthias Blüher & Michael P. Czech & Ira Tabas, 2018. "Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance," Nature, Nature, vol. 555(7698), pages 673-677, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7698:d:10.1038_nature26138
    DOI: 10.1038/nature26138
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