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A TRP channel trio mediates acute noxious heat sensing

Author

Listed:
  • Ine Vandewauw

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

  • Katrien De Clercq

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research
    Laboratory of Experimental Gynecology and Obstetrics, University of Leuven)

  • Marie Mulier

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

  • Katharina Held

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research
    Laboratory of Experimental Gynecology and Obstetrics, University of Leuven)

  • Silvia Pinto

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

  • Nele Van Ranst

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

  • Andrei Segal

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

  • Thierry Voet

    (Laboratory of Reproductive Genomics, University of Leuven)

  • Rudi Vennekens

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

  • Katharina Zimmermann

    (University of Erlangen-Nürnberg)

  • Joris Vriens

    (Laboratory of Experimental Gynecology and Obstetrics, University of Leuven)

  • Thomas Voets

    (Laboratory of Ion Channel Research and TRP Research Platform Leuven (TRPLe), University of Leuven
    VIB Center for Brain & Disease Research)

Abstract

Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.

Suggested Citation

  • Ine Vandewauw & Katrien De Clercq & Marie Mulier & Katharina Held & Silvia Pinto & Nele Van Ranst & Andrei Segal & Thierry Voet & Rudi Vennekens & Katharina Zimmermann & Joris Vriens & Thomas Voets, 2018. "A TRP channel trio mediates acute noxious heat sensing," Nature, Nature, vol. 555(7698), pages 662-666, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7698:d:10.1038_nature26137
    DOI: 10.1038/nature26137
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    Cited by:

    1. Lavanya Moparthi & Viktor Sinica & Vamsi K. Moparthi & Mohamed Kreir & Thibaut Vignane & Milos R. Filipovic & Viktorie Vlachova & Peter M. Zygmunt, 2022. "The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ningbo Chen & Xiaoting Xia & Quratulain Hanif & Fengwei Zhang & Ruihua Dang & Bizhi Huang & Yang Lyu & Xiaoyu Luo & Hucai Zhang & Huixuan Yan & Shikang Wang & Fuwen Wang & Jialei Chen & Xiwen Guan & Y, 2023. "Global genetic diversity, introgression, and evolutionary adaptation of indicine cattle revealed by whole genome sequencing," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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