IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v555y2018i7696d10.1038_nature25975.html
   My bibliography  Save this article

Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults

Author

Listed:
  • Shawn F. Sorrells

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

  • Mercedes F. Paredes

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

  • Arantxa Cebrian-Silla

    (Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED)

  • Kadellyn Sandoval

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

  • Dashi Qi

    (State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Zhongshan Hospital, Fudan University)

  • Kevin W. Kelley

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco)

  • David James

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco)

  • Simone Mayer

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

  • Julia Chang

    (David Geffen School of Medicine, Intellectual Development and Disabilities Research Center, University of California Los Angeles, Los Angeles)

  • Kurtis I. Auguste

    (University of California San Francisco, San Francisco)

  • Edward F. Chang

    (University of California San Francisco, San Francisco)

  • Antonio J. Gutierrez

    (Unidad de Cirugía de la Epilepsia, Hospital Universitario La Fe)

  • Arnold R. Kriegstein

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

  • Gary W. Mathern

    (David Geffen School of Medicine, University of California Los Angeles, Los Angeles
    David Geffen School of Medicine, University of California Los Angeles, Los Angeles)

  • Michael C. Oldham

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

  • Eric J. Huang

    (University of California San Francisco, San Francisco)

  • Jose Manuel Garcia-Verdugo

    (Laboratorio de Neurobiología Comparada, Instituto Cavanilles, Universidad de Valencia, CIBERNED)

  • Zhengang Yang

    (State Key Laboratory of Medical Neurobiology and Institutes of Brain Science, Zhongshan Hospital, Fudan University)

  • Arturo Alvarez-Buylla

    (Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco
    University of California San Francisco, San Francisco)

Abstract

Recruitment of young neurons to the hippocampus decreases rapidly during the first years of life, and neurogenesis does not continue, or is extremely rare, in the adult human brain.

Suggested Citation

  • Shawn F. Sorrells & Mercedes F. Paredes & Arantxa Cebrian-Silla & Kadellyn Sandoval & Dashi Qi & Kevin W. Kelley & David James & Simone Mayer & Julia Chang & Kurtis I. Auguste & Edward F. Chang & Anto, 2018. "Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults," Nature, Nature, vol. 555(7696), pages 377-381, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7696:d:10.1038_nature25975
    DOI: 10.1038/nature25975
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature25975
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature25975?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Barilugbene Boobari Akiene & Nunyor Akiene & Lekpa Kingdom David, 2022. "Neurodegeneration of Pyramidal Cells and Memory Impairment in the Hippocampus of the Brain of Wistar Rats Exposed to X-Ray," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 9(10), pages 54-58, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:555:y:2018:i:7696:d:10.1038_nature25975. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.