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Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Author

Listed:
  • Mark H. T. Stappers

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Alexandra E. Clark

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Vishukumar Aimanianda

    (Unité des Aspergillus, Institut Pasteur)

  • Stefan Bidula

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Delyth M. Reid

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Patawee Asamaphan

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Sarah E. Hardison

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Ivy M. Dambuza

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Isabel Valsecchi

    (Unité des Aspergillus, Institut Pasteur)

  • Bernhard Kerscher

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Anthony Plato

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Carol A. Wallace

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Raif Yuecel

    (Iain Fraser Cytometry Centre, Institute of Medical Sciences, University of Aberdeen)

  • Betty Hebecker

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Maria da Glória Teixeira Sousa

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Cristina Cunha

    (Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
    ICVS/3B’s – PT Government Associate Laboratory)

  • Yan Liu

    (Glycosciences Laboratory, Imperial College London)

  • Ten Feizi

    (Glycosciences Laboratory, Imperial College London)

  • Axel A. Brakhage

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Friedrich Schiller University)

  • Kyung J. Kwon-Chung

    (Molecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH))

  • Neil A. R. Gow

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Matteo Zanda

    (Institute of Medical Sciences, University of Aberdeen)

  • Monica Piras

    (Institute of Medical Sciences, University of Aberdeen)

  • Chiara Zanato

    (Institute of Medical Sciences, University of Aberdeen)

  • Martin Jaeger

    (Radboud University Medical Center)

  • Mihai G. Netea

    (Radboud University Medical Center)

  • Frank L. van de Veerdonk

    (Radboud University Medical Center)

  • João F. Lacerda

    (Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Universidade de Lisboa
    Serviço de Hematologia e Transplantação de Medula, Hospital de Santa Maria)

  • António Campos

    (Serviço de Transplantação de Medula Óssea (STMO), Instituto Português de Oncologia do Porto)

  • Agostinho Carvalho

    (Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
    ICVS/3B’s – PT Government Associate Laboratory)

  • Janet A. Willment

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

  • Jean-Paul Latgé

    (Unité des Aspergillus, Institut Pasteur
    Institute of Microbiology, Chinese Academy of Sciences)

  • Gordon D. Brown

    (Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen Fungal Group, Institute of Medical Sciences)

Abstract

The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.

Suggested Citation

  • Mark H. T. Stappers & Alexandra E. Clark & Vishukumar Aimanianda & Stefan Bidula & Delyth M. Reid & Patawee Asamaphan & Sarah E. Hardison & Ivy M. Dambuza & Isabel Valsecchi & Bernhard Kerscher & Anth, 2018. "Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus," Nature, Nature, vol. 555(7696), pages 382-386, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7696:d:10.1038_nature25974
    DOI: 10.1038/nature25974
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