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Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Author

Listed:
  • Peter W. S. Hill

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Harry G. Leitch

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Cristina E. Requena

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Zhiyi Sun

    (New England Biolabs, Inc.)

  • Rachel Amouroux

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Monica Roman-Trufero

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Malgorzata Borkowska

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Jolyon Terragni

    (New England Biolabs, Inc.)

  • Romualdas Vaisvila

    (New England Biolabs, Inc.)

  • Sarah Linnett

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Hakan Bagci

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London
    Medical Research Council Laboratory of Molecular Biology)

  • Gopuraja Dharmalingham

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Vanja Haberle

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London
    Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC))

  • Boris Lenhard

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

  • Yu Zheng

    (New England Biolabs, Inc.)

  • Sriharsa Pradhan

    (New England Biolabs, Inc.)

  • Petra Hajkova

    (MRC London Institute of Medical Sciences (LMS)
    Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)

Abstract

Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis.

Suggested Citation

  • Peter W. S. Hill & Harry G. Leitch & Cristina E. Requena & Zhiyi Sun & Rachel Amouroux & Monica Roman-Trufero & Malgorzata Borkowska & Jolyon Terragni & Romualdas Vaisvila & Sarah Linnett & Hakan Bagc, 2018. "Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte," Nature, Nature, vol. 555(7696), pages 392-396, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7696:d:10.1038_nature25964
    DOI: 10.1038/nature25964
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