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The mechanism of eukaryotic CMG helicase activation

Author

Listed:
  • Max E. Douglas

    (Chromosome Replication Laboratory, The Francis Crick Institute)

  • Ferdos Abid Ali

    (Macromolecular Machines Laboratory, The Francis Crick Institute)

  • Alessandro Costa

    (Macromolecular Machines Laboratory, The Francis Crick Institute)

  • John F. X. Diffley

    (Chromosome Replication Laboratory, The Francis Crick Institute)

Abstract

In vitro experiments, using purified proteins and an assay that detects DNA unwinding, reveal the mechanism of activation of eukaryotic DNA replication.

Suggested Citation

  • Max E. Douglas & Ferdos Abid Ali & Alessandro Costa & John F. X. Diffley, 2018. "The mechanism of eukaryotic CMG helicase activation," Nature, Nature, vol. 555(7695), pages 265-268, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7695:d:10.1038_nature25787
    DOI: 10.1038/nature25787
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    Citations

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    Cited by:

    1. Almutasem Saleh & Yasunori Noguchi & Ricardo Aramayo & Marina E. Ivanova & Kathryn M. Stevens & Alex Montoya & S. Sunidhi & Nicolas Lopez Carranza & Marcin J. Skwark & Christian Speck, 2022. "The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Zhichun Xu & Jianrong Feng & Daqi Yu & Yunjing Huo & Xiaohui Ma & Wai Hei Lam & Zheng Liu & Xiang David Li & Toyotaka Ishibashi & Shangyu Dang & Yuanliang Zhai, 2023. "Synergism between CMG helicase and leading strand DNA polymerase at replication fork," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Daniel Ramírez Montero & Humberto Sánchez & Edo Veen & Theo Laar & Belén Solano & John F. X. Diffley & Nynke H. Dekker, 2023. "Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Yue Wu & Qiongdan Zhang & Yuhan Lin & Wai Hei Lam & Yuanliang Zhai, 2024. "Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    5. Humberto Sánchez & Zhaowei Liu & Edo Veen & Theo Laar & John F. X. Diffley & Nynke H. Dekker, 2023. "A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Matthew Day & Bilal Tetik & Milena Parlak & Yasser Almeida-Hernández & Markus Räschle & Farnusch Kaschani & Heike Siegert & Anika Marko & Elsa Sanchez-Garcia & Markus Kaiser & Isabel A. Barker & Laure, 2024. "TopBP1 utilises a bipartite GINS binding mode to support genome replication," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    7. Zhihua Kang & Pan Fu & Allen L. Alcivar & Haiqing Fu & Christophe Redon & Tzeh Keong Foo & Yamei Zuo & Caiyong Ye & Ryan Baxley & Advaitha Madireddy & Remi Buisson & Anja-Katrin Bielinsky & Lee Zou & , 2021. "BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    8. Ananya Acharya & Hélène Bret & Jen-Wei Huang & Martin Mütze & Martin Göse & Vera Maria Kissling & Ralf Seidel & Alberto Ciccia & Raphaël Guérois & Petr Cejka, 2024. "Mechanism of DNA unwinding by MCM8-9 in complex with HROB," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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