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The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

Author

Listed:
  • Alessandro Bertero

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
    University of Washington)

  • Stephanie Brown

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Pedro Madrigal

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
    Wellcome Trust Sanger Institute)

  • Anna Osnato

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Daniel Ortmann

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Loukia Yiangou

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Juned Kadiwala

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Nina C. Hubner

    (Radboud University)

  • Igor Ruiz de los Mozos

    (University College London)

  • Christoph Sadée

    (University College London)

  • An-Sofie Lenaerts

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Shota Nakanoh

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Rodrigo Grandy

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Edward Farnell

    (University of Cambridge)

  • Jernej Ule

    (University College London)

  • Hendrik G. Stunnenberg

    (Radboud University)

  • Sasha Mendjan

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
    Institute of Molecular Biotechnology)

  • Ludovic Vallier

    (Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge
    Wellcome Trust Sanger Institute)

Abstract

The SMAD2 and SMAD3 protein interactome links TGFβ signalling to diverse effectors including m6A methyltransferase, which has a role in regulating differentiation of human pluripotent stem cells.

Suggested Citation

  • Alessandro Bertero & Stephanie Brown & Pedro Madrigal & Anna Osnato & Daniel Ortmann & Loukia Yiangou & Juned Kadiwala & Nina C. Hubner & Igor Ruiz de los Mozos & Christoph Sadée & An-Sofie Lenaerts &, 2018. "The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency," Nature, Nature, vol. 555(7695), pages 256-259, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7695:d:10.1038_nature25784
    DOI: 10.1038/nature25784
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    Cited by:

    1. Yasufumi Katanasaka & Harumi Yabe & Noriyuki Murata & Minori Sobukawa & Yuga Sugiyama & Hikaru Sato & Hiroki Honda & Yoichi Sunagawa & Masafumi Funamoto & Satoshi Shimizu & Kana Shimizu & Toshihide Ha, 2024. "Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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