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Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

Author

Listed:
  • Sheng Wang

    (University of North Carolina at Chapel Hill)

  • Tao Che

    (University of North Carolina at Chapel Hill)

  • Anat Levit

    (University of California San Francisco)

  • Brian K. Shoichet

    (University of California San Francisco)

  • Daniel Wacker

    (University of North Carolina at Chapel Hill)

  • Bryan L. Roth

    (University of North Carolina at Chapel Hill
    Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
    National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill)

Abstract

An X-ray structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone reveals an extended binding pocket and indicates structural features that could be used to design drugs that specifically target the D2 receptor.

Suggested Citation

  • Sheng Wang & Tao Che & Anat Levit & Brian K. Shoichet & Daniel Wacker & Bryan L. Roth, 2018. "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone," Nature, Nature, vol. 555(7695), pages 269-273, March.
  • Handle: RePEc:nat:nature:v:555:y:2018:i:7695:d:10.1038_nature25758
    DOI: 10.1038/nature25758
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    Cited by:

    1. Amal El Daibani & Joseph M. Paggi & Kuglae Kim & Yianni D. Laloudakis & Petr Popov & Sarah M. Bernhard & Brian E. Krumm & Reid H. J. Olsen & Jeffrey Diberto & F. Ivy Carroll & Vsevolod Katritch & Bern, 2023. "Molecular mechanism of biased signaling at the kappa opioid receptor," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Xiao Teng & Sijia Chen & Yingying Nie & Peng Xiao & Xiao Yu & Zhenhua Shao & Sanduo Zheng, 2022. "Ligand recognition and biased agonism of the D1 dopamine receptor," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Kevin M. Knight & Brian E. Krumm & Nicholas J. Kapolka & W. Grant Ludlam & Meng Cui & Sepehr Mani & Iya Prytkova & Elizabeth G. Obarow & Tyler J. Lefevre & Wenyuan Wei & Ning Ma & Xi-Ping Huang & Jona, 2024. "A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Sandra Arroyo-Urea & Antonina L. Nazarova & Ángela Carrión-Antolí & Alessandro Bonifazi & Francisco O. Battiti & Jordy Homing Lam & Amy Hauck Newman & Vsevolod Katritch & Javier García-Nafría, 2024. "A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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