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The cryo-electron microscopy structure of huntingtin

Author

Listed:
  • Qiang Guo

    (Max Planck Institute of Biochemistry)

  • Bin Huang

    (Ulm University)

  • Jingdong Cheng

    (Gene Center, Ludwig-Maximilians University)

  • Manuel Seefelder

    (Ulm University)

  • Tatjana Engler

    (Ulm University)

  • Günter Pfeifer

    (Max Planck Institute of Biochemistry)

  • Patrick Oeckl

    (Ulm University)

  • Markus Otto

    (Ulm University)

  • Franziska Moser

    (Boehringer Ingelheim Pharma GmbH & Co. KG)

  • Melanie Maurer

    (Boehringer Ingelheim Pharma GmbH & Co. KG)

  • Alexander Pautsch

    (Boehringer Ingelheim Pharma GmbH & Co. KG)

  • Wolfgang Baumeister

    (Max Planck Institute of Biochemistry)

  • Rubén Fernández-Busnadiego

    (Max Planck Institute of Biochemistry)

  • Stefan Kochanek

    (Ulm University)

Abstract

The structure of huntingtin in complex with an interactor is determined to an overall resolution of 4 Å, paving the way for improved understanding of the cellular functions of this protein.

Suggested Citation

  • Qiang Guo & Bin Huang & Jingdong Cheng & Manuel Seefelder & Tatjana Engler & Günter Pfeifer & Patrick Oeckl & Markus Otto & Franziska Moser & Melanie Maurer & Alexander Pautsch & Wolfgang Baumeister &, 2018. "The cryo-electron microscopy structure of huntingtin," Nature, Nature, vol. 555(7694), pages 117-120, March.
    • Handle: RePEc:nat:nature:v:555:y:2018:i:7694:d:10.1038_nature25502
    DOI: 10.1038/nature25502
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    Cited by:

    1. Zhang, Jiajie & Li, Rui & Zhang, Mengbin & Peng, Jingqi & Fan, Yuchen & Ma, Suxia & Zhang, Jiansheng, 2023. "A novel measurement method for ash deposition based on coplanar capacitance principle: Theoretical, numerical and experimental studies," Energy, Elsevier, vol. 282(C).
    2. Gong-Her Wu & Charlene Smith-Geater & Jesús G. Galaz-Montoya & Yingli Gu & Sanket R. Gupte & Ranen Aviner & Patrick G. Mitchell & Joy Hsu & Ricardo Miramontes & Keona Q. Wang & Nicolette R. Geller & C, 2023. "CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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