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Palladium-catalysed electrophilic aromatic C–H fluorination

Author

Listed:
  • Kumiko Yamamoto

    (Max-Planck-Institut für Kohlenforschung
    Harvard University)

  • Jiakun Li

    (Max-Planck-Institut für Kohlenforschung)

  • Jeffrey A. O. Garber

    (Max-Planck-Institut für Kohlenforschung
    Harvard University)

  • Julian D. Rolfes

    (Max-Planck-Institut für Kohlenforschung
    Harvard University)

  • Gregory B. Boursalian

    (Max-Planck-Institut für Kohlenforschung
    Harvard University)

  • Jannik C. Borghs

    (Harvard University)

  • Christophe Genicot

    (Global Chemistry, UCB NewMedicines, UCB Biopharma)

  • Jérôme Jacq

    (Global Chemistry, UCB NewMedicines, UCB Biopharma)

  • Maurice van Gastel

    (Max-Planck-Institut für Kohlenforschung)

  • Frank Neese

    (Max-Planck-Institut für Kohlenforschung)

  • Tobias Ritter

    (Max-Planck-Institut für Kohlenforschung
    Harvard University)

Abstract

An approach for the direct electrophilic C–H fluorination of arenes is reported, using a palladium catalyst and mild fluorinating reagents.

Suggested Citation

  • Kumiko Yamamoto & Jiakun Li & Jeffrey A. O. Garber & Julian D. Rolfes & Gregory B. Boursalian & Jannik C. Borghs & Christophe Genicot & Jérôme Jacq & Maurice van Gastel & Frank Neese & Tobias Ritter, 2018. "Palladium-catalysed electrophilic aromatic C–H fluorination," Nature, Nature, vol. 554(7693), pages 511-514, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25749
    DOI: 10.1038/nature25749
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