Author
Listed:
- Michael Vanlandewijck
(Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC)
Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Liqun He
(Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City)
- Maarja Andaloussi Mäe
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Johanna Andrae
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Koji Ando
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Francesca Del Gaudio
(Karolinska Institutet)
- Khayrun Nahar
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Thibaud Lebouvier
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University
Inserm U1171, University of Lille, CHU, Memory Center, Distalz)
- Bàrbara Laviña
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Leonor Gouveia
(Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
- Ying Sun
(Zhongyuan Union Genetic Technology Co., Ltd., No.45)
- Elisabeth Raschperger
(Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC))
- Markus Räsänen
(Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki)
- Yvette Zarb
(Zürich University Hospital, Zürich University)
- Naoki Mochizuki
(National Cerebral and Cardiovascular Center Research Institute
AMED-CREST, National Cerebral and Cardiovascular Center)
- Annika Keller
(Zürich University Hospital, Zürich University)
- Urban Lendahl
(Karolinska Institutet)
- Christer Betsholtz
(Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC)
Genetics and Pathology, Rudbeck Laboratory, Uppsala University)
Abstract
Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature.
Suggested Citation
Michael Vanlandewijck & Liqun He & Maarja Andaloussi Mäe & Johanna Andrae & Koji Ando & Francesca Del Gaudio & Khayrun Nahar & Thibaud Lebouvier & Bàrbara Laviña & Leonor Gouveia & Ying Sun & Elisabet, 2018.
"A molecular atlas of cell types and zonation in the brain vasculature,"
Nature, Nature, vol. 554(7693), pages 475-480, February.
Handle:
RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25739
DOI: 10.1038/nature25739
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