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TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Author

Listed:
  • Daniele V. F. Tauriello

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC))

  • Sergio Palomo-Ponce

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC))

  • Diana Stork

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Antonio Berenguer-Llergo

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Jordi Badia-Ramentol

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Mar Iglesias

    (Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
    Hospital del Mar
    Cancer Research Programme, Hospital del Mar Research Institute (IMIM)
    Autonomous University of Barcelona (UAB))

  • Marta Sevillano

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC))

  • Sales Ibiza

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Adrià Cañellas

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Xavier Hernando-Momblona

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC))

  • Daniel Byrom

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Joan A. Matarin

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Alexandre Calon

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Hospital del Mar Research Institute (IMIM))

  • Elisa I. Rivas

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Hospital del Mar Research Institute (IMIM))

  • Angel R. Nebreda

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    ICREA)

  • Antoni Riera

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    University of Barcelona)

  • Camille Stephan-Otto Attolini

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology)

  • Eduard Batlle

    (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
    Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
    ICREA)

Abstract

A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal cancers in mice.

Suggested Citation

  • Daniele V. F. Tauriello & Sergio Palomo-Ponce & Diana Stork & Antonio Berenguer-Llergo & Jordi Badia-Ramentol & Mar Iglesias & Marta Sevillano & Sales Ibiza & Adrià Cañellas & Xavier Hernando-Momblona, 2018. "TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis," Nature, Nature, vol. 554(7693), pages 538-543, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7693:d:10.1038_nature25492
    DOI: 10.1038/nature25492
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