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Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

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  • Yihui Cui

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University
    Mental Health Center, School of Medicine, Zhejiang University)

  • Yan Yang

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University
    Mental Health Center, School of Medicine, Zhejiang University)

  • Zheyi Ni

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Yiyan Dong

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Guohong Cai

    (School of Basic Medicine, Fourth Military Medical University)

  • Alexandre Foncelle

    (INRIA
    University of Lyon)

  • Shuangshuang Ma

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Kangning Sang

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Siyang Tang

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Yuezhou Li

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Ying Shen

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University)

  • Hugues Berry

    (INRIA
    University of Lyon)

  • Shengxi Wu

    (School of Basic Medicine, Fourth Military Medical University)

  • Hailan Hu

    (Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University
    Mental Health Center, School of Medicine, Zhejiang University)

Abstract

Increased expression of the potassium channel Kir4.1 on astrocytes in the lateral habenula drives neuronal bursting in rodent models of depression.

Suggested Citation

  • Yihui Cui & Yan Yang & Zheyi Ni & Yiyan Dong & Guohong Cai & Alexandre Foncelle & Shuangshuang Ma & Kangning Sang & Siyang Tang & Yuezhou Li & Ying Shen & Hugues Berry & Shengxi Wu & Hailan Hu, 2018. "Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression," Nature, Nature, vol. 554(7692), pages 323-327, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25752
    DOI: 10.1038/nature25752
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    Cited by:

    1. Francis Kei Masuda & Emily A. Aery Jones & Yanjun Sun & Lisa M. Giocomo, 2023. "Ketamine evoked disruption of entorhinal and hippocampal spatial maps," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Soo Hyun Yang & Esther Yang & Jaekwang Lee & Jin Yong Kim & Hyeijung Yoo & Hyung Sun Park & Jin Taek Jung & Dongmin Lee & Sungkun Chun & Yong Sang Jo & Gyeong Hee Pyeon & Jae-Yong Park & Hyun Woo Lee , 2023. "Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Danijela Bataveljic & Helena Pivonkova & Vidian de Concini & Betty Hébert & Pascal Ezan & Sylvain Briault & Alexis-Pierre Bemelmans & Jacques Pichon & Arnaud Menuet & Nathalie Rouach, 2024. "Astroglial Kir4.1 potassium channel deficit drives neuronal hyperexcitability and behavioral defects in Fragile X syndrome mouse model," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    4. Shan Yao & Min-Dong Xu & Ying Wang & Shen-Ting Zhao & Jin Wang & Gui-Fu Chen & Wen-Bing Chen & Jian Liu & Guo-Bin Huang & Wen-Juan Sun & Yan-Yan Zhang & Huan-Li Hou & Lei Li & Xiang-Dong Sun, 2023. "Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Shannon Trombley & Jackson Powell & Pavithran Guttipatti & Andrew Matamoros & Xiaohui Lin & Tristan O’Harrow & Tobias Steinschaden & Leann Miles & Qin Wang & Shuchao Wang & Jingyun Qiu & Qingyang Li &, 2023. "Glia instruct axon regeneration via a ternary modulation of neuronal calcium channels in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Andrew Jo & Sercan Deniz & Jian Xu & Robert M. Duvoisin & Steven H. DeVries & Yongling Zhu, 2023. "A sign-inverted receptive field of inhibitory interneurons provides a pathway for ON-OFF interactions in the retina," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Muran Wang & Peijun Li & Zewen Li & Beatriz S. Silva & Wu Zheng & Zhenghua Xiang & Yan He & Tao Xu & Cristina Cordeiro & Lu Deng & Yuwei Dai & Mengqian Ye & Zhiqing Lin & Jianhong Zhou & Xuzhao Zhou &, 2023. "Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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