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Asparagine bioavailability governs metastasis in a model of breast cancer

Author

Listed:
  • Simon R. V. Knott

    (Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
    Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, 8700 Beverly Boulevard)

  • Elvin Wagenblast

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
    Princess Margaret Cancer Centre, University Health Network, University of Toronto
    University of Toronto)

  • Showkhin Khan

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
    New York Genome Center, 101 6th Avenue)

  • Sun Y. Kim

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor)

  • Mar Soto

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor)

  • Michel Wagner

    (The Institute of Cancer Research)

  • Marc-Olivier Turgeon

    (The Institute of Cancer Research)

  • Lisa Fish

    (University of California, San Francisco
    University of California, San Francisco
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco)

  • Nicolas Erard

    (Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way)

  • Annika L. Gable

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor)

  • Ashley R. Maceli

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor)

  • Steffen Dickopf

    (Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor)

  • Evangelia K. Papachristou

    (Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way)

  • Clive S. D’Santos

    (Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way)

  • Lisa A. Carey

    (University of North Carolina at Chapel Hill, 170 Manning Drive, CB7305)

  • John E. Wilkinson

    (University of Michigan School of Medicine)

  • J. Chuck Harrell

    (Virginia Commonwealth University)

  • Charles M. Perou

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill)

  • Hani Goodarzi

    (University of California, San Francisco
    University of California, San Francisco
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco)

  • George Poulogiannis

    (The Institute of Cancer Research
    Imperial College London)

  • Gregory J. Hannon

    (Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way
    Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor
    New York Genome Center, 101 6th Avenue)

Abstract

In a mouse model of breast cancer, asparagine bioavailability strongly influences metastasis and this is correlated with the production of proteins that regulate the epithelial-to-mesenchymal transition, which provides at least one potential mechanism for how a single amino acid could regulate metastatic progression.

Suggested Citation

  • Simon R. V. Knott & Elvin Wagenblast & Showkhin Khan & Sun Y. Kim & Mar Soto & Michel Wagner & Marc-Olivier Turgeon & Lisa Fish & Nicolas Erard & Annika L. Gable & Ashley R. Maceli & Steffen Dickopf &, 2018. "Asparagine bioavailability governs metastasis in a model of breast cancer," Nature, Nature, vol. 554(7692), pages 378-381, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7692:d:10.1038_nature25465
    DOI: 10.1038/nature25465
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