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Dynamic basis for dG•dT misincorporation via tautomerization and ionization

Author

Listed:
  • Isaac J. Kimsey

    (Duke University Medical Center
    Nymirum)

  • Eric S. Szymanski

    (Duke University Medical Center)

  • Walter J. Zahurancik

    (The Ohio State University
    The Ohio State Biochemistry Program, The Ohio State University)

  • Anisha Shakya

    (University of Michigan
    Institute of Basic Science, Center for Soft and Living Matter)

  • Yi Xue

    (Duke University Medical Center
    Tsinghua University)

  • Chia-Chieh Chu

    (Duke University Medical Center)

  • Bharathwaj Sathyamoorthy

    (Duke University Medical Center
    Indian Institute of Science Education and Research Bhopal)

  • Zucai Suo

    (The Ohio State University
    The Ohio State Biochemistry Program, The Ohio State University)

  • Hashim M. Al-Hashimi

    (Duke University Medical Center
    Duke University)

Abstract

A kinetic model is proposed to predict the probability of dG•dT misincorporation across different polymerases, and provides mechanisms for sequence-dependent misincorporation.

Suggested Citation

  • Isaac J. Kimsey & Eric S. Szymanski & Walter J. Zahurancik & Anisha Shakya & Yi Xue & Chia-Chieh Chu & Bharathwaj Sathyamoorthy & Zucai Suo & Hashim M. Al-Hashimi, 2018. "Dynamic basis for dG•dT misincorporation via tautomerization and ionization," Nature, Nature, vol. 554(7691), pages 195-201, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7691:d:10.1038_nature25487
    DOI: 10.1038/nature25487
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    Cited by:

    1. Juntaek Oh & Zelin Shan & Shuichi Hoshika & Jun Xu & Jenny Chong & Steven A. Benner & Dmitry Lyumkis & Dong Wang, 2023. "A unified Watson-Crick geometry drives transcription of six-letter expanded DNA alphabets by E. coli RNA polymerase," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Joonas A. Jamsen & David D. Shock & Samuel H. Wilson, 2022. "Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Ge Han & Yi Xue, 2022. "Rational design of hairpin RNA excited states reveals multi-step transitions," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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