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Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties

Author

Listed:
  • Huan Bao

    (University of Wisconsin–Madison
    Howard Hughes Medical Institute)

  • Debasis Das

    (University of Wisconsin–Madison
    Howard Hughes Medical Institute)

  • Nicholas A. Courtney

    (University of Wisconsin–Madison
    Howard Hughes Medical Institute)

  • Yihao Jiang

    (University of Wisconsin–Madison)

  • Joseph S. Briguglio

    (University of Wisconsin–Madison
    Howard Hughes Medical Institute)

  • Xiaochu Lou

    (University of Wisconsin–Madison
    Howard Hughes Medical Institute)

  • Daniel Roston

    (University of Wisconsin)

  • Qiang Cui

    (University of Wisconsin)

  • Baron Chanda

    (University of Wisconsin–Madison
    University of Wisconsin)

  • Edwin R. Chapman

    (University of Wisconsin–Madison
    Howard Hughes Medical Institute)

Abstract

Analysis at high temporal and spatial resolution shows that the number and dynamics of SNARE proteins available during exocytosis determines the size and stability of fusion pores.

Suggested Citation

  • Huan Bao & Debasis Das & Nicholas A. Courtney & Yihao Jiang & Joseph S. Briguglio & Xiaochu Lou & Daniel Roston & Qiang Cui & Baron Chanda & Edwin R. Chapman, 2018. "Dynamics and number of trans-SNARE complexes determine nascent fusion pore properties," Nature, Nature, vol. 554(7691), pages 260-263, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7691:d:10.1038_nature25481
    DOI: 10.1038/nature25481
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    Citations

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    Cited by:

    1. Ling-Gang Wu & Chung Yu Chan, 2024. "Membrane transformations of fusion and budding," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Bhavya R. Bhaskar & Laxmi Yadav & Malavika Sriram & Kinjal Sanghrajka & Mayank Gupta & Boby K. V & Rohith K. Nellikka & Debasis Das, 2024. "Differential SNARE chaperoning by Munc13-1 and Munc18-1 dictates fusion pore fate at the release site," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Kevin C. Courtney & Taraknath Mandal & Nikunj Mehta & Lanxi Wu & Yueqi Li & Debasis Das & Qiang Cui & Edwin R. Chapman, 2023. "Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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