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The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms

Author

Listed:
  • Markus Alexander Grohme

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Siegfried Schloissnig

    (Heidelberg Institute for Theoretical Studies)

  • Andrei Rozanski

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Martin Pippel

    (Heidelberg Institute for Theoretical Studies)

  • George Robert Young

    (The Francis Crick Institute)

  • Sylke Winkler

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Holger Brandl

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Ian Henry

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Andreas Dahl

    (Deep Sequencing Group, BIOTEC/Center for Regenerative Therapies Dresden, Cluster of Excellence at TU Dresden)

  • Sean Powell

    (Heidelberg Institute for Theoretical Studies)

  • Michael Hiller

    (Max Planck Institute of Molecular Cell Biology and Genetics
    Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Str)

  • Eugene Myers

    (Max Planck Institute of Molecular Cell Biology and Genetics)

  • Jochen Christian Rink

    (Max Planck Institute of Molecular Cell Biology and Genetics)

Abstract

The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.

Suggested Citation

  • Markus Alexander Grohme & Siegfried Schloissnig & Andrei Rozanski & Martin Pippel & George Robert Young & Sylke Winkler & Holger Brandl & Ian Henry & Andreas Dahl & Sean Powell & Michael Hiller & Euge, 2018. "The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms," Nature, Nature, vol. 554(7690), pages 56-61, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7690:d:10.1038_nature25473
    DOI: 10.1038/nature25473
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    Cited by:

    1. Mario Ivanković & Jeremias N. Brand & Luca Pandolfini & Thomas Brown & Martin Pippel & Andrei Rozanski & Til Schubert & Markus A. Grohme & Sylke Winkler & Laura Robledillo & Meng Zhang & Azzurra Codin, 2024. "A comparative analysis of planarian genomes reveals regulatory conservation in the face of rapid structural divergence," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Eudald Pascual-Carreras & Marta Marín-Barba & Sergio Castillo-Lara & Pablo Coronel-Córdoba & Marta Silvia Magri & Grant N. Wheeler & Jose Luis Gómez-Skarmeta & Josep F. Abril & Emili Saló & Teresa Ade, 2023. "Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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