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Mitochondrial translation requires folate-dependent tRNA methylation

Author

Listed:
  • Raphael J. Morscher

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Gregory S. Ducker

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

  • Sophia Hsin-Jung Li

    (Princeton University)

  • Johannes A. Mayer

    (Salzburger Landeskliniken and Paracelsus Medical University)

  • Zemer Gitai

    (Princeton University)

  • Wolfgang Sperl

    (Salzburger Landeskliniken and Paracelsus Medical University)

  • Joshua D. Rabinowitz

    (Lewis-Sigler Institute for Integrative Genomics, Princeton University
    Princeton University)

Abstract

Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation.

Suggested Citation

  • Raphael J. Morscher & Gregory S. Ducker & Sophia Hsin-Jung Li & Johannes A. Mayer & Zemer Gitai & Wolfgang Sperl & Joshua D. Rabinowitz, 2018. "Mitochondrial translation requires folate-dependent tRNA methylation," Nature, Nature, vol. 554(7690), pages 128-132, February.
    • Handle: RePEc:nat:nature:v:554:y:2018:i:7690:d:10.1038_nature25460
    DOI: 10.1038/nature25460
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    Cited by:

    1. Sunita Maharjan & Howard Gamper & Yuka Yamaki & Thomas Christian & Robert Y. Henley & Nan-Sheng Li & Takeo Suzuki & Tsutomu Suzuki & Joseph A. Piccirilli & Meni Wanunu & Erin Seifert & Douglas C. Wall, 2024. "Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Nicole Kiweler & Catherine Delbrouck & Vitaly I. Pozdeev & Laura Neises & Leticia Soriano-Baguet & Kim Eiden & Feng Xian & Mohaned Benzarti & Lara Haase & Eric Koncina & Maryse Schmoetten & Christian , 2022. "Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Seong Eun Lee & Seongyeol Park & Shinae Yi & Na Rae Choi & Mi Ae Lim & Jae Won Chang & Ho-Ryun Won & Je Ryong Kim & Hye Mi Ko & Eun-Jae Chung & Young Joo Park & Sun Wook Cho & Hyeong Won Yu & June You, 2024. "Unraveling the role of the mitochondrial one-carbon pathway in undifferentiated thyroid cancer by multi-omics analyses," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Yanying Wang & Jing Wang & Xiaoyu Li & Xushen Xiong & Jianyi Wang & Ziheng Zhou & Xiaoxiao Zhu & Yang Gu & Dan Dominissini & Lei He & Yong Tian & Chengqi Yi & Zusen Fan, 2021. "N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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