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Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling

Author

Listed:
  • Giulia Pasqual

    (Laboratory of Lymphocyte Dynamics, The Rockefeller University)

  • Aleksey Chudnovskiy

    (Laboratory of Lymphocyte Dynamics, The Rockefeller University)

  • Jeroen M. J. Tas

    (Laboratory of Lymphocyte Dynamics, The Rockefeller University)

  • Marianna Agudelo

    (Laboratory of Lymphocyte Dynamics, The Rockefeller University)

  • Lawrence D. Schweitzer

    (Broad Institute of MIT and Harvard
    Center for Cancer Research, Massachusetts General Hospital)

  • Ang Cui

    (Broad Institute of MIT and Harvard
    Center for Cancer Research, Massachusetts General Hospital)

  • Nir Hacohen

    (Broad Institute of MIT and Harvard
    Center for Cancer Research, Massachusetts General Hospital)

  • Gabriel D. Victora

    (Laboratory of Lymphocyte Dynamics, The Rockefeller University)

Abstract

Interactions between receptors and ligands on immune cells are visualized in vivo and in vitro using an enzyme-tagged ligand that, when cells interact, leaves behind a detectable label on the receptor-expressing cell.

Suggested Citation

  • Giulia Pasqual & Aleksey Chudnovskiy & Jeroen M. J. Tas & Marianna Agudelo & Lawrence D. Schweitzer & Ang Cui & Nir Hacohen & Gabriel D. Victora, 2018. "Monitoring T cell–dendritic cell interactions in vivo by intercellular enzymatic labelling," Nature, Nature, vol. 553(7689), pages 496-500, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25442
    DOI: 10.1038/nature25442
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