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Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication

Author

Listed:
  • Xinghong Dai

    (Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
    The California NanoSystems Institute (CNSI), University of California, Los Angeles (UCLA)
    University of California, Los Angeles (UCLA))

  • Danyang Gong

    (University of California, Los Angeles (UCLA))

  • Hanyoung Lim

    (Immunology and Molecular Genetics, University of California, Los Angeles (UCLA))

  • Jonathan Jih

    (Immunology and Molecular Genetics, University of California, Los Angeles (UCLA))

  • Ting-Ting Wu

    (University of California, Los Angeles (UCLA))

  • Ren Sun

    (The California NanoSystems Institute (CNSI), University of California, Los Angeles (UCLA)
    University of California, Los Angeles (UCLA))

  • Z. Hong Zhou

    (Immunology and Molecular Genetics, University of California, Los Angeles (UCLA)
    The California NanoSystems Institute (CNSI), University of California, Los Angeles (UCLA))

Abstract

Cryo-electron microscopy reveals the structure of the Kaposi’s sarcoma-associated herpesvirus capsid, and experiments with polypeptides that mimic the smallest capsid protein demonstrate the potential for structure-derived insights to help to develop antiviral agents.

Suggested Citation

  • Xinghong Dai & Danyang Gong & Hanyoung Lim & Jonathan Jih & Ting-Ting Wu & Ren Sun & Z. Hong Zhou, 2018. "Structure and mutagenesis reveal essential capsid protein interactions for KSHV replication," Nature, Nature, vol. 553(7689), pages 521-525, January.
    • Handle: RePEc:nat:nature:v:553:y:2018:i:7689:d:10.1038_nature25438
    DOI: 10.1038/nature25438
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    Cited by:

    1. Guosong Wang & Zhenghui Zha & Pengfei Huang & Hui Sun & Yang Huang & Maozhou He & Tian Chen & Lina Lin & Zhenqin Chen & Zhibo Kong & Yuqiong Que & Tingting Li & Ying Gu & Hai Yu & Jun Zhang & Qingbing, 2022. "Structures of pseudorabies virus capsids," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Zhihai Li & Jingjing Pang & Rongchao Gao & Qingxia Wang & Maoyan Zhang & Xuekui Yu, 2023. "Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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